How far is Maysville, MO from O'Fallon, MO?
The driving distance from Maysville, MO to O'Fallon, MO is about 256.7 miles (413.1 km), with a travel time of about 04h 10m by car.
- The straight-line flight distance is about 209.3 miles (336.9 km).
- For a round trip, plan for roughly 08h 20m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 10m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Shelby County, Missouri
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Maysville and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between Maysville and O'Fallon.
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1
Start on West Main Street
712 ft · 16 sec · West Main Street
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2
Turn right onto South Polk Street
8.9 mi · 16 min · South Polk Street
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3
Turn left
162 mi · 3 hr 8 min
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4
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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5
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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6
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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7
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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8
Take the ramp right
37 m · 3 sec
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9
Merge slight left onto Avenue of the Saints
73.7 mi · 1 hr 27 min · Avenue of the Saints
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10
Take the exit slight left toward I 70 East: Saint Louis
2705 ft · 51 sec
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11
Merge slight left onto Dwight D Eisenhower Highway
6.4 mi · 8 min · Dwight D Eisenhower Highway
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12
Take the exit slight right toward MO K: O'Fallon
1765 ft · 43 sec
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13
Turn straight onto Drennen Parkway
46 m · 3 sec · Drennen Parkway
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14
Keep slight right to continue on Drennen Parkway
51 m · 6 sec · Drennen Parkway
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15
Turn slight left onto MO K: O'Fallon
19 m · 3 sec
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16
Continue on South Main Street
3115 ft · 2 min · South Main Street
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17
Turn right
8 m · 2 sec
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18
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Maysville and O'Fallon.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Longest stretch
Turn left
162 mi · 03h 08m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Maysville and Mostly Sunny near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Maysville to O'Fallon?
The road trip is about 256.7 miles (413.1 km) and usually takes 04h 10m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Clarence is a useful midpoint, sitting about 127.6 miles from Maysville and 129.1 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 209.3 miles (336.9 km), while the road route adds roughly 47.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:40 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $34.17 one way or $68.33 round trip. Estimated CO2 is about 80.5 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Maysville and Mostly Sunny near O'Fallon.
Stop Ideas Near Clarence
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Clarence.
La Plata
Quincy
Flight Path Map
This map shows the direct air route between Maysville and O'Fallon. Straight-line distance: 209.35 mi (336.92 km).
#1 Maysville
City in DeKalb County, Missouri, United States
| Population | 1,073 |
| Coordinates | 39.8891700, -94.3619000 |
| Altitude | 296 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 413 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 33m |
| 40 mph (64.37 km/h) | 06h 25m |
| 50 mph (80.47 km/h) | 05h 08m |
| 60 mph (96.56 km/h) | 04h 16m |
| 70 mph (112.65 km/h) | 03h 40m |
| 80 mph (129 km/h) | 03h 12m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $34.17 | $68.33 |
| Mid-grade | $4.25 | $38.53 | $77.06 |
| Premium | $4.65 | $42.17 | $84.33 |
| Diesel | $5.30 | $48.05 | $96.11 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.