How far is Maryville, MO from Cape Girardeau, MO?
The driving distance from Maryville, MO to Cape Girardeau, MO is about 449.6 miles (723.5 km), with a travel time of about 06h 43m by car.
- The straight-line flight distance is about 356.5 miles (573.8 km).
- For a round trip, plan for roughly 13h 27m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 43m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
The most populous city in the state of Missouri.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Maryville and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Maryville and Cape Girardeau.
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1
Start on East 1st Street
41 m · 10 sec · East 1st Street
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2
Turn left onto South Main Street
2.2 mi · 4 min · South Main Street
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3
Continue on US 71 (MO)
30 mi · 34 min · US 71 (MO)
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4
Take the exit slight left toward I 29 South, US 71 South, US 59 South: Kansas City
3.2 mi · 4 min
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5
Continue straight
37.1 mi · 40 min
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6
Merge slight right
2.2 mi · 2 min
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7
Keep slight right to continue on I 435 East: Saint Louis
28 mi · 31 min
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8
Keep slight right to continue on I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
1500 ft · 23 sec
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9
Keep slight left to continue on I 70 East: Saint Louis
1.2 mi · 2 min
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10
Keep slight left to continue on I 70 East: Saint Louis
143 m · 12 sec
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11
Merge slight left onto George Brett Super Highway
2213 ft · 29 sec · George Brett Super Highway
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12
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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13
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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14
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
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15
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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16
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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17
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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18
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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19
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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20
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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21
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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22
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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23
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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24
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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25
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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26
Merge slight left
11.5 mi · 14 min
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27
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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28
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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29
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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30
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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31
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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32
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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33
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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34
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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35
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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36
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Maryville and Cape Girardeau.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Chance Rain Showers leaving Maryville and Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Maryville to Cape Girardeau?
The road trip is about 449.6 miles (723.5 km) and usually takes 06h 43m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Columbia is a useful midpoint, sitting about 222.9 miles from Maryville and 226.6 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 356.5 miles (573.8 km), while the road route adds roughly 93.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $59.81 one way or $119.62 round trip. Estimated CO2 is about 140.9 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers around Maryville and Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Columbia
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Columbia.
Jefferson City
Sedalia
Hermann
Flight Path Map
This map shows the direct air route between Maryville and Cape Girardeau. Straight-line distance: 356.52 mi (573.77 km).
#1 Maryville
City in Nodaway County, Missouri, United States
| Population | 11,530 |
| Coordinates | 40.3461000, -94.8724700 |
| Altitude | 351 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 723 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 14h 58m |
| 40 mph (64.37 km/h) | 11h 14m |
| 50 mph (80.47 km/h) | 08h 59m |
| 60 mph (96.56 km/h) | 07h 29m |
| 70 mph (112.65 km/h) | 06h 25m |
| 80 mph (129 km/h) | 05h 36m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $59.81 | $119.62 |
| Mid-grade | $4.25 | $67.45 | $134.91 |
| Premium | $4.65 | $73.81 | $147.62 |
| Diesel | $5.30 | $84.12 | $168.24 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.