How far is Louisville, KY from Middlesboro, KY?
The driving distance from Louisville, KY to Middlesboro, KY is about 206.2 miles (331.8 km), with a travel time of about 03h 53m by car.
- The straight-line flight distance is about 159.6 miles (256.9 km).
- For a round trip, plan for roughly 07h 47m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 53m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in and the county seat of Madison County, Kentucky, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Partly Sunny
Driving Route Map
The map below follows the saved road route between Louisville and Middlesboro.
Turn-by-Turn Driving Directions
Step-by-step road directions between Louisville and Middlesboro.
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1
Start on West Jefferson Street
1611 ft · 1 min · West Jefferson Street
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2
Turn right onto Roy Wilkins Avenue
535 ft · 11 sec · Roy Wilkins Avenue
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3
Take the ramp straight toward I 64 West, I 64 East: New Albany, Saint Louis, Lexington
139 m · 11 sec
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4
Keep slight right to continue on I 64 East: Lexington
1063 ft · 26 sec
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5
Merge slight right
102.3 mi · 1 hr 53 min
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6
Continue straight
56.7 mi · 1 hr 1 min
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7
Take the exit slight right toward US 25, US 25E: Corbin, Barbourville
1752 ft · 38 sec
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8
Turn left onto Corbin Bypass
2 mi · 3 min · Corbin Bypass
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9
Continue on Cumberland Gap Parkway
30.7 mi · 37 min · Cumberland Gap Parkway
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10
Continue on Bob Madon Bypass
5.3 mi · 7 min · Bob Madon Bypass
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11
Continue on Wilderness Road
5.2 mi · 6 min · Wilderness Road
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12
Continue on Pineville Road
1.6 km · 1 min · Pineville Road
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13
Continue on 12th Street
1.6 km · 1 min · 12th Street
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14
Turn right onto East Cumberland Avenue
1.3 km · 2 min · East Cumberland Avenue
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15
Turn right onto 21st Street
155 m · 28 sec · 21st Street
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16
Turn left onto Lothbury Avenue
53 m · 8 sec · Lothbury Avenue
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17
Arrive at your destination
0 m · 1 sec · Lothbury Avenue
Car Route Details
A richer read on the saved driving route between Louisville and Middlesboro.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 64 East
Merge slight right
102 mi · 01h 53m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Louisville and Partly Sunny near Middlesboro.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Louisville to Middlesboro?
The road trip is about 206.2 miles (331.8 km) and usually takes 03h 53m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Richmond is a useful midpoint, sitting about 103.1 miles from Louisville and 103.1 miles from Middlesboro.
How much longer is the road route than the straight-line distance?
The direct path is about 159.6 miles (256.9 km), while the road route adds roughly 46.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 9:12 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $27.45 one way or $54.91 round trip. Estimated CO2 is about 64.7 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Louisville and Partly Sunny near Middlesboro.
Stop Ideas Near Richmond
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Richmond.
Maysville
Flight Path Map
This map shows the direct air route between Louisville and Middlesboro. Straight-line distance: 159.66 mi (256.94 km).
#1 Louisville
The nineteenth most populous city in the United States and the center of the Louisville metropolitan area.
| Population | 760,026 |
| Coordinates | 38.2542400, -85.7594100 |
| Altitude | 142 |
| Country | United States |
#2 Middlesboro
City in Bell County, Kentucky, United States of America
| Population | 10,730 |
| Coordinates | 36.6084200, -83.7165800 |
| Altitude | 348 |
| Country | United States |
End: Middlesboro (-83.71658, 36.60842)
Estimated Travel Time
Distance: 332 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 52m |
| 40 mph (64.37 km/h) | 05h 09m |
| 50 mph (80.47 km/h) | 04h 07m |
| 60 mph (96.56 km/h) | 03h 26m |
| 70 mph (112.65 km/h) | 02h 56m |
| 80 mph (129 km/h) | 02h 34m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $27.45 | $54.91 |
| Mid-grade | $4.25 | $30.96 | $61.92 |
| Premium | $4.65 | $33.88 | $67.76 |
| Diesel | $5.30 | $38.61 | $77.23 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Kentucky · May 30, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.