How far is Knox, IN from Jeffersonville, IN?
The driving distance from Knox, IN to Jeffersonville, IN is about 233.6 miles (376 km), with a travel time of about 04h 12m by car.
- The straight-line flight distance is about 213.8 miles (344.1 km).
- For a round trip, plan for roughly 08h 24m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 12m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
The sixteenth most populous city in the United States and the center of the Indianapolis metropolitan area.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Knox and Jeffersonville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Knox and Jeffersonville.
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1
Start on the route
25 m · 11 sec
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2
Turn left onto West John Street
1172 ft · 54 sec · West John Street
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3
Turn right onto South Heaton Street
1.7 mi · 3 min · South Heaton Street
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4
Continue on South 400 E
3.9 mi · 5 min · South 400 E
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5
Continue on S 400 E
1.4 mi · 2 min · S 400 E
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6
Continue on South 400 East
11.3 mi · 17 min · South 400 East
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7
Continue on South Huddleston Road
25.3 mi · 37 min · South Huddleston Road
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8
At the end of the road, turn right
30.7 mi · 45 min
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9
Continue straight
17.5 mi · 26 min
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10
Enter the roundabout and take exit 2 toward US 421
40 m · 2 sec · South Michigan Road
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11
Exit the rotary onto South Michigan Road
15.9 mi · 26 min · South Michigan Road
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12
Continue on Dr Martin Luther King Jr Street
1.6 km · 2 min · Dr Martin Luther King Jr Street
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13
Take the ramp slight right toward I 65 South
864 ft · 21 sec
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14
Merge slight left onto Kenneth "Babyface" Edmonds Highway
3.6 mi · 5 min · Kenneth "Babyface" Edmonds Highway
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15
Continue on I 70 East: Dayton
1.9 mi · 3 min
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16
Keep slight left
108.3 mi · 1 hr 59 min
-
17
Take the exit slight right toward US 31 South: Jeffersonville, Clarksville
1515 ft · 32 sec
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18
Turn straight
1.2 km · 1 min
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19
Turn slight right
2590 ft · 2 min
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20
Continue on East 10th Street
128 m · 12 sec · East 10th Street
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21
Turn right onto Wall Street
1086 ft · 38 sec · Wall Street
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22
Turn left onto East 8th Street
1254 ft · 33 sec · East 8th Street
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23
Turn right onto Watt Street
795 ft · 35 sec · Watt Street
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24
Arrive at your destination
0 m · 1 sec · Watt Street
Car Route Details
A richer read on the saved driving route between Knox and Jeffersonville.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
I 70 East
Keep slight left
108 mi · 01h 59m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Knox and Sunny near Jeffersonville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Knox to Jeffersonville?
The road trip is about 233.6 miles (376 km) and usually takes 04h 12m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Indianapolis is a useful midpoint, sitting about 112.7 miles from Knox and 121 miles from Jeffersonville.
How much longer is the road route than the straight-line distance?
The direct path is about 213.8 miles (344.1 km), while the road route adds roughly 19.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:36 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $31.07 one way or $62.15 round trip. Estimated CO2 is about 73.2 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Knox and Jeffersonville, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Knox and Sunny near Jeffersonville.
Stop Ideas Near Indianapolis
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Avon Town Hall Park
Carmel City Hall
Thomas A. Weaver Municipal Complex
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Indianapolis.
Indianapolis Union Station
Crawfordsville
Crawfordsville (Bus), Indiana
Connersville station
Flight Path Map
This map shows the direct air route between Knox and Jeffersonville. Straight-line distance: 213.8 mi (344.08 km).
#1 Knox
City in Center Township, Starke County, Indiana, United States
| Population | 3,597 |
| Coordinates | 41.2958800, -86.6250100 |
| Altitude | 217 |
| Country | United States |
#2 Jeffersonville
The most populous city in Clark County, Indiana.
| Population | 48,530 |
| Coordinates | 38.2775700, -85.7371800 |
| Altitude | 136 |
| Country | United States |
End: Watt Street (-85.737805, 38.277274)
Estimated Travel Time
Distance: 376 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 47m |
| 40 mph (64.37 km/h) | 05h 50m |
| 50 mph (80.47 km/h) | 04h 40m |
| 60 mph (96.56 km/h) | 03h 53m |
| 70 mph (112.65 km/h) | 03h 20m |
| 80 mph (129 km/h) | 02h 54m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $31.07 | $62.15 |
| Mid-grade | $4.25 | $35.04 | $70.09 |
| Premium | $4.65 | $38.35 | $76.70 |
| Diesel | $5.30 | $43.70 | $87.41 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Indiana · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.