How far is Knox City, TX from San Antonio, TX?
The driving distance from Knox City, TX to San Antonio, TX is about 320.9 miles (516.5 km), with a travel time of about 05h 16m by car.
- The straight-line flight distance is about 286.8 miles (461.6 km).
- For a round trip, plan for roughly 10h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 16m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Concho County, Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Driving Route Map
The map below follows the saved road route between Knox City and San Antonio.
Turn-by-Turn Driving Directions
Step-by-step road directions between Knox City and San Antonio.
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1
Start on East Main Street
14 m · 8 sec · East Main Street
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2
Turn left onto South Central Avenue
1 mi · 2 min · South Central Avenue
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3
Continue on State Highway 6
1.6 mi · 2 min · State Highway 6
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4
Continue on Grand Central Avenue
1.3 km · 1 min · Grand Central Avenue
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5
Continue on State Highway 6
12.7 mi · 19 min · State Highway 6
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6
Continue on Union Avenue
18.2 mi · 27 min · Union Avenue
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7
Turn right
600 ft · 10 sec
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8
Take the ramp slight left
1509 ft · 41 sec
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9
Merge slight left
16.1 mi · 18 min
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10
Turn slight right onto Commercial Avenue
32.5 mi · 35 min · Commercial Avenue
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11
Continue straight
7.8 mi · 9 min
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12
Continue straight
39.5 mi · 45 min
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13
Turn left onto South 7th Street
16.5 mi · 18 min · South 7th Street
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14
Continue on Grassmeyer Street
41.9 mi · 45 min · Grassmeyer Street
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15
Continue on Ellis Street
29.4 mi · 31 min · Ellis Street
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16
Take the exit left toward I 10 East: San Antonio
40 mi · 38 min
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17
Continue straight
54.3 mi · 55 min
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18
Keep slight right
17.4 mi · 20 min
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19
Keep slight right to continue on McDermott Freeway
1.7 mi · 2 min · McDermott Freeway
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20
Take the exit slight right toward Santa Rosa Street, Downtown
2505 ft · 1 min
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21
Turn straight onto North Pecos-La Trinidad
804 ft · 16 sec · North Pecos-La Trinidad
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22
Keep slight right to continue on North Pecos-La Trinidad
2963 ft · 1 min · North Pecos-La Trinidad
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23
Turn left onto Dolorosa Street
2582 ft · 56 sec · Dolorosa Street
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24
Arrive at your destination
0 m · 1 sec · Dolorosa Street
Car Route Details
A richer read on the saved driving route between Knox City and San Antonio.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 10 East
Continue straight
54.3 mi · 00h 55m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Knox City and Partly Sunny near San Antonio.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Knox City to San Antonio?
The road trip is about 320.9 miles (516.5 km) and usually takes 05h 16m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Eden is a useful midpoint, sitting about 167 miles from Knox City and 154 miles from San Antonio.
How much longer is the road route than the straight-line distance?
The direct path is about 286.8 miles (461.6 km), while the road route adds roughly 34.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:26 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.82 one way or $85.63 round trip. Estimated CO2 is about 100.7 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Knox City and Partly Sunny near San Antonio.
Flight Path Map
This map shows the direct air route between Knox City and San Antonio. Straight-line distance: 286.8 mi (461.56 km).
#1 Knox City
City in Knox County, Texas, United States
| Population | 1,120 |
| Coordinates | 33.4181500, -99.8189800 |
| Altitude | 466 |
| Country | United States |
#2 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
End: Dolorosa Street (-98.493645, 29.424163)
Estimated Travel Time
Distance: 517 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 41m |
| 40 mph (64.37 km/h) | 08h 01m |
| 50 mph (80.47 km/h) | 06h 25m |
| 60 mph (96.56 km/h) | 05h 20m |
| 70 mph (112.65 km/h) | 04h 35m |
| 80 mph (129 km/h) | 04h 00m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $42.82 | $85.63 |
| Mid-grade | $4.25 | $48.18 | $96.35 |
| Premium | $4.59 | $52.02 | $104.03 |
| Diesel | $3.99 | $45.24 | $90.48 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Jun 01, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.