How far is Kirksville, MO from Saint Charles, MO?
The driving distance from Kirksville, MO to Saint Charles, MO is about 188.5 miles (303.4 km), with a travel time of about 03h 08m by car.
- The straight-line flight distance is about 148.5 miles (239 km).
- For a round trip, plan for roughly 06h 17m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 08m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Kirksville and Saint Charles.
Turn-by-Turn Driving Directions
Step-by-step road directions between Kirksville and Saint Charles.
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1
Start on North Franklin Street
898 ft · 42 sec · North Franklin Street
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2
Turn right onto East Illinois Street
3125 ft · 1 min · East Illinois Street
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3
Turn right onto North Baltimore Street
4 mi · 6 min · North Baltimore Street
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4
Take the ramp straight toward US 63 South: Macon
766 ft · 21 sec
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5
Merge slight left
28.6 mi · 32 min
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6
Take the exit left toward US 36 East, MO 110 East: Hannibal
929 ft · 12 sec
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7
Merge slight left onto Chicago-Kansas City Expressway
52.9 mi · 1 hr 1 min · Chicago-Kansas City Expressway
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8
Continue on V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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9
Take the exit slight right toward Veterans Road
1167 ft · 30 sec
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10
Turn right onto Veterans Road
2.1 mi · 4 min · Veterans Road
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11
At the end of the road, turn left onto County Road 422
85 m · 7 sec · County Road 422
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12
Continue on Paris Gravel Road
2539 ft · 1 min · Paris Gravel Road
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13
Take the ramp right
37 m · 3 sec
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14
Merge slight left onto Avenue of the Saints
73.7 mi · 1 hr 27 min · Avenue of the Saints
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15
Take the exit slight left toward I 70 East: Saint Louis
2705 ft · 51 sec
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16
Merge slight left onto Dwight D Eisenhower Highway
17.1 mi · 21 min · Dwight D Eisenhower Highway
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17
Take the exit slight right toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
653 ft · 14 sec
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18
Keep slight left to continue on I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
596 ft · 15 sec
-
19
Turn straight onto First Capitol Drive
1.5 km · 2 min · First Capitol Drive
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20
Turn slight right onto MO 94
1.4 km · 2 min
-
21
Turn left onto South Second Street
1551 ft · 57 sec · South Second Street
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22
Arrive at your destination
0 m · 1 sec · North Second Street
Car Route Details
A richer read on the saved driving route between Kirksville and Saint Charles.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Avenue of the Saints
Merge slight left onto Avenue of the Saints
73.7 mi · 01h 27m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms leaving Kirksville and Showers And Thunderstorms near Saint Charles.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Kirksville to Saint Charles?
The road trip is about 188.5 miles (303.4 km) and usually takes 03h 08m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Hannibal is a useful midpoint, sitting about 94.4 miles from Kirksville and 94 miles from Saint Charles.
How much longer is the road route than the straight-line distance?
The direct path is about 148.5 miles (239 km), while the road route adds roughly 40 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:42 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $25.08 one way or $50.15 round trip. Estimated CO2 is about 59.1 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Kirksville and Showers And Thunderstorms near Saint Charles.
Stop Ideas Near Hannibal
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Hannibal.
Quincy
Fort Madison station
Macomb
La Plata
Flight Path Map
This map shows the direct air route between Kirksville and Saint Charles. Straight-line distance: 148.53 mi (239.04 km).
#1 Kirksville
City in Adair County, Missouri, United States
| Population | 17,653 |
| Coordinates | 40.1947500, -92.5832500 |
| Altitude | 299 |
| Country | United States |
#2 Saint Charles
A city in St.
| Population | 71,761 |
| Coordinates | 38.7839400, -90.4812300 |
| Altitude | 147 |
| Country | United States |
End: North Second Street (-90.481269, 38.783952)
Estimated Travel Time
Distance: 303 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 16m |
| 40 mph (64.37 km/h) | 04h 42m |
| 50 mph (80.47 km/h) | 03h 46m |
| 60 mph (96.56 km/h) | 03h 08m |
| 70 mph (112.65 km/h) | 02h 41m |
| 80 mph (129 km/h) | 02h 21m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $25.08 | $50.15 |
| Mid-grade | $4.25 | $28.28 | $56.56 |
| Premium | $4.65 | $30.95 | $61.90 |
| Diesel | $5.30 | $35.27 | $70.54 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.