How far is Jacksonville, FL from North Key Largo, FL?
The driving distance from Jacksonville, FL to North Key Largo, FL is about 395.8 miles (637 km), with a travel time of about 07h 27m by car.
- The straight-line flight distance is about 359.3 miles (578.2 km).
- For a round trip, plan for roughly 14h 54m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 27m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Indian River County, Florida, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Jacksonville and North Key Largo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Jacksonville and North Key Largo.
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1
Start on Union Street
596 ft · 21 sec · Union Street
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2
Turn right onto Newnan Street
1965 ft · 1 min · Newnan Street
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3
Turn right onto East Forsyth Street
770 ft · 24 sec · East Forsyth Street
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4
Turn left onto Main Street
2507 ft · 1 min · Main Street
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5
Take the ramp straight toward I 95 South
1.5 km · 2 min
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6
Keep slight right to continue on I 95, US 1 South, FL 5 South: Daytona Beach, Philips Highway
1165 ft · 28 sec
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7
Keep slight left to continue on I 95 South: Daytona Beach
1093 ft · 27 sec
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8
Merge slight left
219.5 mi · 3 hr 57 min
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9
Take the exit slight right toward FL 70: Okeechobee, Fort Pierce
2396 ft · 58 sec
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10
Keep slight right to continue on FL 70 West: Okeechobee
150 m · 12 sec
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11
Merge slight left onto Okeechobee Road
2745 ft · 58 sec · Okeechobee Road
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12
Take the ramp left
1090 ft · 35 sec
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13
Keep slight left to continue on Miami, Florida's Turnpike South
2588 ft · 1 min
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14
Merge slight left onto Florida's Turnpike
105.2 mi · 1 hr 56 min · Florida's Turnpike
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15
Take the exit slight right toward Florida's Turnpike Toll South, Homestead
1197 ft · 20 sec · Homestead Extension of Florida's Turnpike
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16
Keep slight left to continue on Homestead Extension of Florida's Turnpike
46.9 mi · 54 min · Homestead Extension of Florida's Turnpike
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17
Keep slight left
2930 ft · 1 min
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18
Merge slight left onto Dixie Highway
1 mi · 2 min · Dixie Highway
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19
Turn left onto Card Sound Road
16.5 mi · 23 min · Card Sound Road
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20
Turn right
1.7 mi · 3 min
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21
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Jacksonville and North Key Largo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 95 South
Merge slight left
219 mi · 03h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Showers And Thunderstorms leaving Jacksonville and Chance Showers And Thunderstorms near North Key Largo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Jacksonville to North Key Largo?
The road trip is about 395.8 miles (637 km) and usually takes 07h 27m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Fellsmere is a useful midpoint, sitting about 198.4 miles from Jacksonville and 197.4 miles from North Key Largo.
How much longer is the road route than the straight-line distance?
The direct path is about 359.3 miles (578.2 km), while the road route adds roughly 36.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $57.95 one way or $115.90 round trip. Estimated CO2 is about 124.2 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Jacksonville and Chance Showers And Thunderstorms near North Key Largo.
Stop Ideas Near Fellsmere
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Fellsmere.
Okeechobee
Sebring
Kissimmee
Orlando Health/Amtrak
Flight Path Map
This map shows the direct air route between Jacksonville and North Key Largo. Straight-line distance: 359.28 mi (578.21 km).
#1 Jacksonville
The thirteenth most populous city in the United States and the center of the Jacksonville metropolitan area.
| Population | 920,570 |
| Coordinates | 30.3321800, -81.6556500 |
| Altitude | 5 |
| Country | United States |
#2 North Key Largo
Census-designated place in Monroe County, Florida, United States
| Population | 1,244 |
| Coordinates | 25.2673400, -80.3233900 |
| Altitude | 0 |
| Country | United States |
End: North Key Largo (-80.32339, 25.26734)
Estimated Travel Time
Distance: 637 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 11m |
| 40 mph (64.37 km/h) | 09h 53m |
| 50 mph (80.47 km/h) | 07h 54m |
| 60 mph (96.56 km/h) | 06h 35m |
| 70 mph (112.65 km/h) | 05h 39m |
| 80 mph (129 km/h) | 04h 56m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $57.95 | $115.90 |
| Mid-grade | $4.60 | $64.21 | $128.41 |
| Premium | $4.90 | $68.40 | $136.79 |
| Diesel | $4.35 | $60.77 | $121.54 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · May 13, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.