How far is Holtsville, NY from Syracuse, NY?
The driving distance from Holtsville, NY to Syracuse, NY is about 304.4 miles (489.9 km), with a travel time of about 05h 20m by car.
- The straight-line flight distance is about 221.8 miles (357 km).
- For a round trip, plan for roughly 10h 40m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 20m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Sullivan County, New York, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers
Rain Showers Likely
Driving Route Map
The map below follows the saved road route between Holtsville and Syracuse.
Turn-by-Turn Driving Directions
Step-by-step road directions between Holtsville and Syracuse.
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1
Start on Union Avenue
23 m · 9 sec · Union Avenue
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2
Turn left onto Waverly Avenue
2425 ft · 1 min · Waverly Avenue
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3
Turn left onto Express Drive North
1.2 km · 1 min · Express Drive North
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4
Take the ramp slight left toward I-495 west: New York
892 ft · 22 sec
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5
Merge slight left onto Long Island Expressway
37.2 mi · 50 min · Long Island Expressway
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6
Take the exit slight right toward Cross Island Parkway, Whitestone Bridge, Kennedy Airport
1267 ft · 27 sec
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7
Keep slight right to continue on Cross Island Parkway North, Whitestone Bridge
1604 ft · 38 sec
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8
Merge slight left onto Cross Island Parkway
3.1 mi · 5 min · Cross Island Parkway
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9
Take the exit slight right toward I 295 North: Throgs Neck Bridge, Bronx, New England
2905 ft · 1 min
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10
Merge slight left onto Throgs Neck Bridge
1.8 mi · 3 min · Throgs Neck Bridge
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11
Continue on Throgs Neck Expressway
1.1 km · 1 min · Throgs Neck Expressway
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12
Keep slight left to continue on Cross Bronx Expressway
6.6 mi · 9 min · Cross Bronx Expressway
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13
Keep slight left to continue on Trans-Manhattan Expressway
1.1 km · 1 min · Trans-Manhattan Expressway
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14
Continue on George Washington Bridge (upper level)
3167 ft · 60 sec · George Washington Bridge (upper level)
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15
Continue straight
2659 ft · 48 sec
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16
Keep slight left
3214 ft · 39 sec
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17
Keep slight left
559 ft · 9 sec
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18
Take the exit slight right toward I 95 South, NJTP South: Hackensack
1270 ft · 23 sec
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19
Keep slight left to continue on I 95 South, NJTP South: Hackensack
1884 ft · 29 sec
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20
Merge slight left onto New Jersey Turnpike
2 mi · 3 min · New Jersey Turnpike
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21
Take the exit slight right toward I 80 West: Paterson, Hackensack
1.3 km · 1 min
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22
Continue on Christopher Columbus Highway
68.2 mi · 1 hr 21 min · Christopher Columbus Highway
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23
Keep slight left to continue on Keystone Shortway
5.5 mi · 8 min · Keystone Shortway
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24
Keep slight left to continue on Keystone Shortway
11.9 mi · 16 min · Keystone Shortway
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25
Take the exit slight right toward I 380 North: Scranton
1.1 km · 46 sec
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26
Continue straight
27.7 mi · 31 min
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27
Merge slight right
58.1 mi · 1 hr 9 min
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28
Keep slight right to continue on I 81 North: Syracuse, Albany
1.8 mi · 2 min
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29
Keep slight left to continue on I 81 North: Syracuse
66.5 mi · 1 hr 17 min
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30
Keep slight left to continue on Syracuse
1159 ft · 18 sec
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31
Continue straight
2193 ft · 27 sec
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32
Continue straight
1.9 mi · 3 min
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33
Take the exit slight right toward Adams Street, Harrison Street
1421 ft · 37 sec
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34
Continue on Almond Street
1718 ft · 38 sec · Almond Street
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35
Turn left onto East Genesee Street
1448 ft · 37 sec · East Genesee Street
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36
At the end of the road, turn right onto South State Street
3 m · 1 sec · South State Street
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37
Arrive at your destination
0 m · 1 sec · South State Street
Car Route Details
A richer read on the saved driving route between Holtsville and Syracuse.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Christopher Columbus Highway
Continue on Christopher Columbus Highway
68.2 mi · 01h 21m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Rain Showers leaving Holtsville and Rain Showers Likely near Syracuse.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Holtsville to Syracuse?
The road trip is about 304.4 miles (489.9 km) and usually takes 05h 20m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Tusten is a useful midpoint, sitting about 150.7 miles from Holtsville and 153.7 miles from Syracuse.
How much longer is the road route than the straight-line distance?
The direct path is about 221.8 miles (357 km), while the road route adds roughly 82.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:20 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $43.06 one way or $86.11 round trip. Estimated CO2 is about 95.4 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers around Holtsville and Rain Showers Likely near Syracuse.
Stop Ideas Near Tusten
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Tusten.
Scranton, PA
White Haven, PA
Wilkes-Barre, PA
Poughkeepsie station
Flight Path Map
This map shows the direct air route between Holtsville and Syracuse. Straight-line distance: 221.84 mi (357.02 km).
#1 Holtsville
Census-designated place in Suffolk County, New York
| Population | 19,714 |
| Coordinates | 40.8153800, -73.0451100 |
| Altitude | 32 |
| Country | United States |
#2 Syracuse
The fifth most populous city in New York.
| Population | 141,229 |
| Coordinates | 43.0481200, -76.1474200 |
| Altitude | 121 |
| Country | United States |
End: South State Street (-76.14744, 43.04812)
Estimated Travel Time
Distance: 490 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 08m |
| 40 mph (64.37 km/h) | 07h 36m |
| 50 mph (80.47 km/h) | 06h 05m |
| 60 mph (96.56 km/h) | 05h 04m |
| 70 mph (112.65 km/h) | 04h 20m |
| 80 mph (129 km/h) | 03h 47m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.01 | $43.06 | $86.11 |
| Mid-grade | $4.48 | $48.13 | $96.25 |
| Premium | $4.86 | $52.21 | $104.41 |
| Diesel | $4.69 | $50.41 | $100.83 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in New York · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.