How far is Greenville, NC from Simpsonville, SC?
The driving distance from Greenville, NC to Simpsonville, SC is about 342.1 miles (550.6 km), with a travel time of about 06h 42m by car.
- The straight-line flight distance is about 282.6 miles (454.8 km).
- For a round trip, plan for roughly 13h 25m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 42m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Randolph County, North Carolina, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Greenville and Simpsonville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville and Simpsonville.
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1
Start on South Summit Street
1161 ft · 53 sec · South Summit Street
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2
At the end of the road, turn right onto East 5th Street
1500 ft · 1 min · East 5th Street
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3
Turn left onto South Evans Street
1907 ft · 55 sec · South Evans Street
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4
Turn right onto West 10th Street
1.1 km · 1 min · West 10th Street
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5
Continue on Farmville Boulevard
2718 ft · 50 sec · Farmville Boulevard
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6
Continue on Stantonsburg Road
2.5 mi · 4 min · Stantonsburg Road
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7
Continue on John P East Memorial Highway
32.8 mi · 35 min · John P East Memorial Highway
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8
Merge slight right
29.8 mi · 32 min
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9
Take the exit slight right toward Rolesville Road
1173 ft · 29 sec
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10
Keep slight right to continue on Rolesville Road
94 m · 8 sec
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11
Turn right onto Rolesville Road
2.4 mi · 4 min · Rolesville Road
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12
Turn sharp left onto Marks Creek Road
2050 ft · 39 sec · Marks Creek Road
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13
Turn right onto Horton Road
2310 ft · 44 sec · Horton Road
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14
Turn right onto Buffaloe Road
3.8 mi · 7 min · Buffaloe Road
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15
Take the ramp right
1943 ft · 24 sec
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16
Merge slight left onto Northern Wake Expressway
15.4 mi · 17 min · Northern Wake Expressway
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17
Take the exit slight right toward US 70 West: Durham
2972 ft · 1 min
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18
Merge slight left onto Glenwood Avenue
1.9 mi · 3 min · Glenwood Avenue
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19
Continue on New Raleigh Highway
2.5 mi · 4 min · New Raleigh Highway
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20
Continue on South Miami Boulevard
9.3 mi · 12 min · South Miami Boulevard
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21
Keep slight left
42.3 mi · 49 min
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22
Keep slight right
7.7 mi · 9 min
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23
Keep slight left to continue on I 85 Business South, US 29 South, US 70 West: Charlotte
5.4 mi · 6 min
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24
Keep slight left
173.4 mi · 3 hr 18 min
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25
Take the exit slight right toward I 385, SC 146: Columbia, Greenville, Woodruff Road
2469 ft · 1 min
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26
Keep slight right to continue on I 385 South: Columbia
1.1 mi · 2 min
-
27
Keep slight left to continue on I 385 South: Columbia
1 km · 1 min
-
28
Merge slight left onto Golden Strip Freeway
3.5 mi · 4 min · Golden Strip Freeway
-
29
Keep slight right to continue on Southern Connector
2035 ft · 25 sec · Southern Connector
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30
Take the exit slight right toward SC 417: Simpsonville
979 ft · 32 sec
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31
Turn left onto Northeast Main Street
2.4 mi · 5 min · Northeast Main Street
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32
Turn left onto East Curtis Street
114 m · 10 sec · East Curtis Street
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33
Turn right onto Hedge Street
45 m · 7 sec · Hedge Street
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34
Turn right
53 m · 18 sec
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35
Turn left
33 m · 8 sec
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36
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Greenville and Simpsonville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 85 Business South
Keep slight left
173 mi · 03h 18m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Greenville and Sunny near Simpsonville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Greenville to Simpsonville?
The road trip is about 342.1 miles (550.6 km) and usually takes 06h 42m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Trinity is a useful midpoint, sitting about 170.6 miles from Greenville and 171.5 miles from Simpsonville.
How much longer is the road route than the straight-line distance?
The direct path is about 282.6 miles (454.8 km), while the road route adds roughly 59.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $45.31 one way or $90.62 round trip. Estimated CO2 is about 107.3 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Greenville and Sunny near Simpsonville.
Stop Ideas Near Trinity
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Trinity.
High Point
J. Douglas Galyon Depot
Lexington
Winston-Salem State Univ, Winston-Salem, North Car
Flight Path Map
This map shows the direct air route between Greenville and Simpsonville. Straight-line distance: 282.57 mi (454.76 km).
#1 Greenville
The most populous city in Pitt County, North Carolina.
| Population | 94,779 |
| Coordinates | 35.6126600, -77.3663500 |
| Altitude | 18 |
| Country | United States |
#2 Simpsonville
City in Greenville County, South Carolina, United States of America
| Population | 25,272 |
| Coordinates | 34.7370600, -82.2542800 |
| Altitude | 262 |
| Country | United States |
End: Simpsonville (-82.25428, 34.73706)
Estimated Travel Time
Distance: 551 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 24m |
| 40 mph (64.37 km/h) | 08h 33m |
| 50 mph (80.47 km/h) | 06h 50m |
| 60 mph (96.56 km/h) | 05h 42m |
| 70 mph (112.65 km/h) | 04h 53m |
| 80 mph (129 km/h) | 04h 16m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.75 | $45.31 | $90.62 |
| Mid-grade | $4.23 | $51.06 | $102.11 |
| Premium | $4.63 | $55.82 | $111.65 |
| Diesel | $5.72 | $69.03 | $138.06 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in North Carolina · Oct 15, 2026