How far is De Pere, WI from La Crosse, WI?
The driving distance from De Pere, WI to La Crosse, WI is about 216.7 miles (348.7 km), with a travel time of about 03h 39m by car.
- The straight-line flight distance is about 163.9 miles (263.8 km).
- For a round trip, plan for roughly 07h 19m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 39m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Civil town in Marquette County, Wisconsin
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between De Pere and La Crosse.
Turn-by-Turn Driving Directions
Step-by-step road directions between De Pere and La Crosse.
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1
Start on South Broadway
140 m · 8 sec · South Broadway
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2
Enter the roundabout and take exit 1 toward Main Avenue
6 m · 1 sec · Main Avenue
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3
Exit the roundabout onto Main Avenue
1.4 mi · 3 min · Main Avenue
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4
Enter the roundabout and take exit 2 toward West Main Avenue
28 m · 2 sec · West Main Avenue
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5
Exit the roundabout onto West Main Avenue
105 m · 7 sec · West Main Avenue
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6
Enter the roundabout and take exit 2 toward West Main Avenue
31 m · 2 sec · West Main Avenue
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7
Exit the roundabout onto West Main Avenue
892 ft · 18 sec · West Main Avenue
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8
Enter the roundabout and take exit 1 toward Appleton
7 m · 1 sec
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9
Exit the roundabout onto Appleton
3022 ft · 1 min
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10
Merge slight left
46.4 mi · 50 min
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11
Take the exit slight right toward WI 44, WI 91
1444 ft · 35 sec
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12
Keep slight right
56 m · 5 sec
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13
Turn right onto Ripon Rd
1.3 km · 1 min · Ripon Rd
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14
Continue on State Highway 44
14.8 mi · 22 min · State Highway 44
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15
Continue on East Oshkosh Street
1.5 mi · 4 min · East Oshkosh Street
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16
Turn right onto West Fond du Lac Street
1.4 mi · 3 min · West Fond du Lac Street
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17
Continue on State Highway 23 & 49
3.7 mi · 5 min · State Highway 23 & 49
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18
Turn straight onto State Highway 23
9.2 mi · 13 min · State Highway 23
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19
Continue on South Fulton Street
1.2 km · 1 min · South Fulton Street
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20
Turn left onto West Main Street
1.3 km · 1 min · West Main Street
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21
Turn left
46 m · 3 sec
-
22
Continue on South 2nd Street
2515 ft · 43 sec · South 2nd Street
-
23
Continue on State Highway 23
9.9 mi · 15 min · State Highway 23
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24
Continue on East Montello Street
3142 ft · 57 sec · East Montello Street
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25
Continue on West Montello Street
635 ft · 11 sec · West Montello Street
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26
Turn slight right onto Underwood Avenue
1.8 mi · 3 min · Underwood Avenue
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27
Continue on State Highway 23
6.1 mi · 8 min · State Highway 23
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28
Continue on State Highway 82
3.5 mi · 5 min · State Highway 82
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29
Continue on East Ormsby Street
1.1 mi · 2 min · East Ormsby Street
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30
Continue on State Highway 82
24.5 mi · 36 min · State Highway 82
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31
Keep slight right
85 m · 5 sec
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32
Take the ramp right
1756 ft · 43 sec
-
33
Merge slight left
23.5 mi · 25 min
-
34
Keep slight left to continue on I 90 West: Tomah, La Crosse
39.1 mi · 42 min
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35
Take the exit slight right toward WI 16: La Crosse, Onalaska
1636 ft · 42 sec
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36
At the end of the road, turn left
4.9 mi · 9 min
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37
Continue on Losey Boulevard North
2575 ft · 2 min · Losey Boulevard North
-
38
Turn right onto Main Street
1.1 km · 2 min · Main Street
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39
Turn left onto 16th Street South
1.3 km · 2 min · 16th Street South
-
40
Turn right onto Johnson Street
1824 ft · 1 min · Johnson Street
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41
At the end of the road, turn right onto West Avenue South
99 m · 11 sec · West Avenue South
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42
Arrive at your destination
0 m · 1 sec · West Avenue South
Car Route Details
A richer read on the saved driving route between De Pere and La Crosse.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Appleton
Merge slight left
46.4 mi · 00h 50m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving De Pere and Sunny near La Crosse.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from De Pere to La Crosse?
The road trip is about 216.7 miles (348.7 km) and usually takes 03h 39m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Packwaukee is a useful midpoint, sitting about 100.2 miles from De Pere and 116.4 miles from La Crosse.
How much longer is the road route than the straight-line distance?
The direct path is about 163.9 miles (263.8 km), while the road route adds roughly 52.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 9:40 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $28.85 one way or $57.70 round trip. Estimated CO2 is about 68 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around De Pere and Sunny near La Crosse.
Stop Ideas Near Packwaukee
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Packwaukee.
Westfield, WI
Portage
Wisconsin Dells
Columbus
Flight Path Map
This map shows the direct air route between De Pere and La Crosse. Straight-line distance: 163.89 mi (263.75 km).
#1 De Pere
City in Brown County, Wisconsin
| Population | 25,014 |
| Coordinates | 44.4488800, -88.0603800 |
| Altitude | 183 |
| Country | United States |
#2 La Crosse
The most populous city in La Crosse County, Wisconsin.
| Population | 51,163 |
| Coordinates | 43.8013600, -91.2395800 |
| Altitude | 204 |
| Country | United States |
End: West Avenue South (-91.239623, 43.801338)
Estimated Travel Time
Distance: 349 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 13m |
| 40 mph (64.37 km/h) | 05h 25m |
| 50 mph (80.47 km/h) | 04h 19m |
| 60 mph (96.56 km/h) | 03h 36m |
| 70 mph (112.65 km/h) | 03h 05m |
| 80 mph (129 km/h) | 02h 42m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $28.85 | $57.70 |
| Mid-grade | $4.25 | $32.54 | $65.07 |
| Premium | $4.65 | $35.60 | $71.21 |
| Diesel | $5.30 | $40.58 | $81.15 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Wisconsin · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.