How far is Caruthersville, MO from East Independence, MO?
The driving distance from Caruthersville, MO to East Independence, MO is about 421.3 miles (678 km), with a travel time of about 06h 25m by car.
- The straight-line flight distance is about 326 miles (524.6 km).
- For a round trip, plan for roughly 12h 51m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 25m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Village in the United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Chance Showers And Thunderstorms then Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Caruthersville and East Independence.
Turn-by-Turn Driving Directions
Step-by-step road directions between Caruthersville and East Independence.
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1
Start on the route
14 m · 9 sec
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2
Turn left onto West 3rd Street
2.9 mi · 6 min · West 3rd Street
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3
Continue straight
2 mi · 4 min
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4
Take the ramp right toward I 55 North, US 61 North: Sikeston
1331 ft · 33 sec
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5
Merge slight left
74.2 mi · 1 hr 20 min
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6
Keep slight left
101.5 mi · 1 hr 49 min
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7
Continue on Rosa Parks Highway
1.3 mi · 2 min · Rosa Parks Highway
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8
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
1279 ft · 27 sec
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9
Keep slight left to continue on I 270 West: Kansas City
118 m · 8 sec
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10
Continue on I 270 West
1.2 km · 1 min
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11
Merge slight left
11.5 mi · 14 min
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12
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
705 ft · 17 sec
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13
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
2009 ft · 49 sec
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14
Continue on I 64 West, US 40 West, US 61 North: Wentzville
674 ft · 10 sec
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15
Merge slight left onto Avenue of the Saints
25.4 mi · 31 min · Avenue of the Saints
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16
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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17
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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18
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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19
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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20
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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21
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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22
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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23
Take the exit slight right toward Little Blue Parkway, 39th Street, Mall Entrance
1652 ft · 40 sec
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24
Turn right onto South Little Blue Parkway
1.6 mi · 3 min · South Little Blue Parkway
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25
Turn left onto East R.D. Mize Road
1301 ft · 38 sec · East R.D. Mize Road
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26
Turn right onto South Jackson Drive
1.2 mi · 2 min · South Jackson Drive
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27
Turn straight onto Holke Road
1.4 km · 2 min · Holke Road
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28
Turn left onto East Truman Road
1.1 km · 1 min · East Truman Road
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29
Turn right onto Main Road
1341 ft · 1 min · Main Road
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30
Turn right onto East 9th Street South
24 m · 3 sec · East 9th Street South
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31
Arrive at your destination
0 m · 1 sec · East 9th Street South
Car Route Details
A richer read on the saved driving route between Caruthersville and East Independence.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 55 North
Keep slight left
102 mi · 01h 49m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Partly Sunny leaving Caruthersville and Chance Showers And Thunderstorms then Showers And Thunderstorms near East Independence.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Caruthersville to East Independence?
The road trip is about 421.3 miles (678 km) and usually takes 06h 25m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Weldon Spring Heights is a useful midpoint, sitting about 209.7 miles from Caruthersville and 211.6 miles from East Independence.
How much longer is the road route than the straight-line distance?
The direct path is about 326 miles (524.6 km), while the road route adds roughly 95.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $56.04 one way or $112.07 round trip. Estimated CO2 is about 132.1 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around Caruthersville and Chance Showers And Thunderstorms then Showers And Thunderstorms near East Independence.
Stop Ideas Near Weldon Spring Heights
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Park
City of O'Fallon
Swingley Ridge @ Chesterfield City Hall SB
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Weldon Spring Heights.
Kirkwood
Washington
Gateway Transportation Center
Alton
Flight Path Map
This map shows the direct air route between Caruthersville and East Independence. Straight-line distance: 325.99 mi (524.63 km).
#1 Caruthersville
City in and county seat of Pemiscot County, Missouri, United States
| Population | 5,289 |
| Coordinates | 36.1931200, -89.6556400 |
| Altitude | 84 |
| Country | United States |
#2 East Independence
A census-designated place in Jackson County, Missouri.
| Population | 110,675 |
| Coordinates | 39.0955600, -94.3552300 |
| Altitude | 256 |
| Country | United States |
End: East 9th Street South (-94.355237, 39.09539)
Estimated Travel Time
Distance: 678 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 14h 02m |
| 40 mph (64.37 km/h) | 10h 31m |
| 50 mph (80.47 km/h) | 08h 25m |
| 60 mph (96.56 km/h) | 07h 01m |
| 70 mph (112.65 km/h) | 06h 01m |
| 80 mph (129 km/h) | 05h 15m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $56.04 | $112.07 |
| Mid-grade | $4.25 | $63.20 | $126.40 |
| Premium | $4.65 | $69.16 | $138.32 |
| Diesel | $5.30 | $78.82 | $157.63 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.