How far is Cape Coral, FL from Panama City, FL?
The driving distance from Cape Coral, FL to Panama City, FL is about 499 miles (803 km), with a travel time of about 09h 34m by car.
- The straight-line flight distance is about 335.5 miles (540 km).
- For a round trip, plan for roughly 19h 08m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 09h 34m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
The third most populous city in Florida.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Cape Coral and Panama City.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Coral and Panama City.
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1
Start on the route
29 m · 7 sec
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2
Turn right onto Cape Coral Parkway East
38 m · 7 sec · Cape Coral Parkway East
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3
Turn right onto Vincennes Boulevard
109 m · 13 sec · Vincennes Boulevard
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4
Enter the roundabout and take exit 2 toward Vincennes Boulevard
19 m · 2 sec · Vincennes Boulevard
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5
Exit the roundabout onto Vincennes Boulevard
2436 ft · 1 min · Vincennes Boulevard
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6
Turn right onto Coronado Parkway
1 km · 2 min · Coronado Parkway
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7
Turn left onto Del Prado Boulevard South
5.2 mi · 11 min · Del Prado Boulevard South
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8
Continue on Del Prado Boulevard North
6.5 mi · 11 min · Del Prado Boulevard North
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9
Turn left onto North Tamiami Trail
10.4 mi · 13 min · North Tamiami Trail
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10
Turn right onto Tuckers Grade
1.1 mi · 2 min · Tuckers Grade
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11
Take the ramp slight left toward I 75 North: Tampa
2299 ft · 56 sec
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12
Merge slight left
276.8 mi · 4 hr 58 min
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13
Take the exit slight right toward I 10: Jacksonville, Tallahassee
820 ft · 16 sec
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14
Keep slight left to continue on I 10 West: Tallahassee
1569 ft · 30 sec
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15
Merge slight right
121.8 mi · 2 hr 11 min
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16
Take the exit slight right toward FL 12: Gretna, Greensboro
1341 ft · 46 sec
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17
Keep slight left to continue on FL `12 South: Greensboro
112 m · 11 sec
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18
Turn straight onto Greensboro Highway
2.4 mi · 4 min · Greensboro Highway
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19
Continue on Selman Street
3018 ft · 1 min · Selman Street
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20
Turn left onto Green Avenue
2342 ft · 57 sec · Green Avenue
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21
Continue on Bristol Highway
17.7 mi · 23 min · Bristol Highway
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22
At the end of the road, turn right
28.4 mi · 39 min
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23
Turn left
24.1 mi · 32 min
-
24
Turn left onto Harrison Avenue
1 mi · 3 min · Harrison Avenue
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25
Turn left onto East 7th Street
69 m · 12 sec · East 7th Street
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26
Turn right onto Luverne Avenue
131 m · 19 sec · Luverne Avenue
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27
Arrive at your destination
0 m · 1 sec · Luverne Avenue
Car Route Details
A richer read on the saved driving route between Cape Coral and Panama City.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 75 North
Merge slight left
277 mi · 04h 58m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Cape Coral and Sunny near Panama City.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cape Coral to Panama City?
The road trip is about 499 miles (803 km) and usually takes 09h 34m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Gainesville is a useful midpoint, sitting about 249.7 miles from Cape Coral and 249.3 miles from Panama City.
How much longer is the road route than the straight-line distance?
The direct path is about 335.5 miles (540 km), while the road route adds roughly 163.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM EDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $73.05 one way or $146.09 round trip. Estimated CO2 is about 156.5 kg one way.
Do you cross a time zone on this route?
Yes. There is about a 1 hour time difference between Cape Coral and Panama City, so arrival and return times should be read in local time.
What should you check before leaving?
Before you leave, expect Sunny around Cape Coral and Sunny near Panama City.
Stop Ideas Near Gainesville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Gainesville.
Gainesville, Florida
Waldo, Florida
Ocala, Florida
Palatka
Flight Path Map
This map shows the direct air route between Cape Coral and Panama City. Straight-line distance: 335.57 mi (540.05 km).
#1 Cape Coral
The second most populous city in Lee County, Florida.
| Population | 200,972 |
| Coordinates | 26.5628500, -81.9495300 |
| Altitude | 1 |
| Country | United States |
#2 Panama City
County seat of Bay County, Florida, United States
| Population | 34,667 |
| Coordinates | 30.1594600, -85.6598300 |
| Altitude | 8 |
| Country | United States |
End: Panama City (-85.65983, 30.15946)
Estimated Travel Time
Distance: 803 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 16h 37m |
| 40 mph (64.37 km/h) | 12h 28m |
| 50 mph (80.47 km/h) | 09h 58m |
| 60 mph (96.56 km/h) | 08h 18m |
| 70 mph (112.65 km/h) | 07h 07m |
| 80 mph (129 km/h) | 06h 13m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.15 | $73.05 | $146.09 |
| Mid-grade | $4.60 | $80.94 | $161.87 |
| Premium | $4.90 | $86.22 | $172.44 |
| Diesel | $4.35 | $76.60 | $153.21 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Florida · Apr 17, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.