How far is Biloxi, MS from Saltillo, MS?
The driving distance from Biloxi, MS to Saltillo, MS is about 317.1 miles (510.3 km), with a travel time of about 06h 12m by car.
- The straight-line flight distance is about 275.3 miles (443 km).
- For a round trip, plan for roughly 12h 24m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 12m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in and the county seat of Lauderdale County, Mississippi, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Biloxi and Saltillo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi and Saltillo.
-
1
Start on Howard Avenue
28 m · 6 sec · Howard Avenue
-
2
Turn right onto Main Street
2572 ft · 1 min · Main Street
-
3
Turn left onto Division Street
2603 ft · 2 min · Division Street
-
4
Take the ramp right toward Bohn Street
42 m · 3 sec · Bohn Street
-
5
Turn straight
1522 ft · 37 sec
-
6
Merge slight left
3.1 mi · 4 min
-
7
Continue straight
20.7 mi · 24 min
-
8
Keep slight right to continue on US 49 North: Hattiesburg, Jackson
2209 ft · 47 sec
-
9
Merge slight left
39.8 mi · 47 min
-
10
Continue straight
2.4 mi · 3 min
-
11
Take the exit straight
1520 ft · 52 sec
-
12
Merge slight left
2.5 mi · 3 min
-
13
Take the exit slight right toward I 59 North, US 98 West: Columbia, Laurel
1.3 km · 2 min
-
14
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
88.4 mi · 1 hr 35 min · Lance Corporal Roy M Wheat Memorial Highway
-
15
Keep slight right to continue on I 59 North, I 20 East: Meridian, Tuscaloosa
9 mi · 11 min
-
16
Take the exit slight right toward US 45 North: Macon
1383 ft · 47 sec
-
17
Merge slight left
65.1 mi · 1 hr 14 min
-
18
Keep slight left to continue on US Highway 45 Alternate
53 mi · 1 hr 4 min · US Highway 45 Alternate
-
19
Continue on Martin Luther King Drive
18.1 mi · 21 min · Martin Luther King Drive
-
20
Continue on Martin Luther King, Junior Drive
3.3 mi · 4 min · Martin Luther King, Junior Drive
-
21
Keep slight right
7.1 mi · 8 min
-
22
Take the exit slight right
1824 ft · 45 sec
-
23
Keep slight right
104 m · 8 sec
-
24
Turn straight
1088 ft · 22 sec
-
25
Turn slight right
138 m · 20 sec
-
26
Continue straight
115 m · 20 sec
-
27
Turn left onto Kyle Avenue
1597 ft · 1 min · Kyle Avenue
-
28
At the end of the road, turn left
2751 ft · 2 min
-
29
Continue on East Mobile Street
153 m · 10 sec · East Mobile Street
-
30
Arrive at your destination
0 m · 1 sec · East Mobile Street
Car Route Details
A richer read on the saved driving route between Biloxi and Saltillo.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Lance Corporal Roy M Wheat Memorial Highway
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
88.4 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Biloxi and Sunny near Saltillo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Biloxi to Saltillo?
The road trip is about 317.1 miles (510.3 km) and usually takes 06h 12m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Meridian is a useful midpoint, sitting about 158.8 miles from Biloxi and 158.3 miles from Saltillo.
How much longer is the road route than the straight-line distance?
The direct path is about 275.3 miles (443 km), while the road route adds roughly 41.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.38 one way or $84.75 round trip. Estimated CO2 is about 99.4 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Biloxi and Sunny near Saltillo.
Stop Ideas Near Meridian
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Meridian.
Union Station
Laurel station
Thomasville, AL
Grove Hill, AL
Flight Path Map
This map shows the direct air route between Biloxi and Saltillo. Straight-line distance: 275.28 mi (443.02 km).
#1 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
#2 Saltillo
Human settlement in Lee County, Mississippi, United States of America
| Population | 5,071 |
| Coordinates | 34.3764900, -88.6817200 |
| Altitude | 98 |
| Country | United States |
End: Saltillo (-88.68172, 34.37649)
Estimated Travel Time
Distance: 510 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 33m |
| 40 mph (64.37 km/h) | 07h 55m |
| 50 mph (80.47 km/h) | 06h 20m |
| 60 mph (96.56 km/h) | 05h 17m |
| 70 mph (112.65 km/h) | 04h 31m |
| 80 mph (129 km/h) | 03h 57m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $42.38 | $84.75 |
| Mid-grade | $4.26 | $47.66 | $95.32 |
| Premium | $4.63 | $51.75 | $103.51 |
| Diesel | $5.42 | $60.59 | $121.19 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.