How far is Wentzville, MO from Sikeston, MO?
The driving distance from Wentzville, MO to Sikeston, MO is about 171.7 miles (276.3 km), with a travel time of about 03h 14m by car.
- The straight-line flight distance is about 150.4 miles (242.1 km).
- For a round trip, plan for roughly 06h 28m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 14m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in and the county seat of Ste.
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Wentzville and Sikeston.
Turn-by-Turn Driving Directions
Step-by-step road directions between Wentzville and Sikeston.
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1
Start on East Allen Street
12 m · 4 sec · East Allen Street
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2
Turn right onto North Linn Avenue
65 m · 11 sec · North Linn Avenue
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3
Turn right onto East Pearce Boulevard
2469 ft · 1 min · East Pearce Boulevard
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4
Turn slight right
106 m · 9 sec
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5
Turn slight right onto Luetkenhaus Boulevard
152 m · 14 sec · Luetkenhaus Boulevard
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6
Take the ramp straight toward US 61 South, I 70, US 40
50 m · 2 sec
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7
Keep slight left to continue on US 61 South
772 ft · 11 sec
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8
Merge slight left onto Avenue of the Saints
25.5 mi · 31 min · Avenue of the Saints
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9
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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10
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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11
Merge slight left
11.5 mi · 14 min
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12
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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13
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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14
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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15
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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16
Continue on Police Officer Steven Jarvis Memorial Highway
125.8 mi · 2 hr 15 min · Police Officer Steven Jarvis Memorial Highway
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17
Take the exit slight right toward US 62: Sikeston, Bertrand
1057 ft · 38 sec
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18
At the end of the road, turn left onto East Malone Avenue
3.1 mi · 5 min · East Malone Avenue
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19
Turn slight right
54 m · 14 sec
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20
Turn left
33 m · 5 sec
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21
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Wentzville and Sikeston.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
126 mi · 02h 15m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Wentzville and Sunny near Sikeston.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Wentzville to Sikeston?
The road trip is about 171.7 miles (276.3 km) and usually takes 03h 14m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Sainte Genevieve is a useful midpoint, sitting about 85.9 miles from Wentzville and 85.8 miles from Sikeston.
How much longer is the road route than the straight-line distance?
The direct path is about 150.4 miles (242.1 km), while the road route adds roughly 21.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:32 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $22.85 one way or $45.70 round trip. Estimated CO2 is about 53.9 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Wentzville and Sunny near Sikeston.
Stop Ideas Near Sainte Genevieve
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Sainte Genevieve.
Du Quoin
Gateway Transportation Center
Kirkwood
Carbondale station
Flight Path Map
This map shows the direct air route between Wentzville and Sikeston. Straight-line distance: 150.44 mi (242.11 km).
#1 Wentzville
A city in St.
| Population | 43,109 |
| Coordinates | 38.8114400, -90.8529100 |
| Altitude | 190 |
| Country | United States |
#2 Sikeston
City in Scott County, Missouri, United States
| Population | 15,968 |
| Coordinates | 36.8767200, -89.5878600 |
| Altitude | 100 |
| Country | United States |
End: Sikeston (-89.58786, 36.87672)
Estimated Travel Time
Distance: 276 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 43m |
| 40 mph (64.37 km/h) | 04h 17m |
| 50 mph (80.47 km/h) | 03h 26m |
| 60 mph (96.56 km/h) | 02h 51m |
| 70 mph (112.65 km/h) | 02h 27m |
| 80 mph (129 km/h) | 02h 08m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $22.85 | $45.70 |
| Mid-grade | $4.25 | $25.77 | $51.55 |
| Premium | $4.65 | $28.20 | $56.41 |
| Diesel | $5.30 | $32.14 | $64.28 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.