How far is Tupelo, MS from Florence, MS?
The driving distance from Tupelo, MS to Florence, MS is about 202.5 miles (325.9 km), with a travel time of about 04h 03m by car.
- The straight-line flight distance is about 167.1 miles (269 km).
- For a round trip, plan for roughly 08h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 03m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Winston County, Mississippi, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Tupelo and Florence.
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo and Florence.
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1
Start on North Spring Street
21 m · 5 sec · North Spring Street
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2
Turn right onto Court Street
97 m · 16 sec · Court Street
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3
Turn right onto North Front Street
87 m · 15 sec · North Front Street
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4
Turn left onto East Main Street
2407 ft · 1 min · East Main Street
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5
Take the ramp straight
2248 ft · 56 sec
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6
Merge slight left onto Martin Luther King Drive
1.6 km · 1 min · Martin Luther King Drive
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7
Continue on Martin Luther King, Junior Drive
2.3 mi · 3 min · Martin Luther King, Junior Drive
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8
Continue on Martin Luther King Drive
7.7 mi · 9 min · Martin Luther King Drive
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9
Continue straight
1.4 mi · 2 min
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10
Continue straight
2.2 mi · 2 min
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11
Continue straight
1.5 mi · 2 min
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12
Continue straight
1.1 km · 49 sec
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13
Continue straight
1.4 mi · 2 min
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14
Continue on US Highway 45 Alternate
35.7 mi · 44 min · US Highway 45 Alternate
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15
Take the exit slight right toward US 82 West, MS 12 West, MS 25 South: Starkville
11.8 mi · 13 min
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16
Take the exit slight right toward MS 25 South: Louisville
5 mi · 7 min
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17
Continue straight
1.9 mi · 2 min
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18
Keep slight right
24.9 mi · 28 min
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19
Take the exit slight right
89.9 mi · 1 hr 43 min
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20
Turn left onto Treetop Boulevard
3046 ft · 1 min · Treetop Boulevard
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21
Turn right onto Flowood Drive
4.1 mi · 7 min · Flowood Drive
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22
Continue on Highway 49 South
9.1 mi · 12 min · Highway 49 South
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23
Take the exit slight right
85 m · 8 sec
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24
Turn straight onto MS 469
2044 ft · 41 sec · MS 469
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25
Arrive at your destination
0 m · 1 sec · MS 469
Car Route Details
A richer read on the saved driving route between Tupelo and Florence.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
MS 25 South
Take the exit slight right
89.9 mi · 01h 43m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Tupelo and Mostly Sunny near Florence.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Tupelo to Florence?
The road trip is about 202.5 miles (325.9 km) and usually takes 04h 03m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Louisville is a useful midpoint, sitting about 101.3 miles from Tupelo and 101.2 miles from Florence.
How much longer is the road route than the straight-line distance?
The direct path is about 167.1 miles (269 km), while the road route adds roughly 35.4 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:52 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $27.08 one way or $54.15 round trip. Estimated CO2 is about 63.5 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Tupelo and Mostly Sunny near Florence.
Stop Ideas Near Louisville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Louisville.
Union Station
Greenwood
Flight Path Map
This map shows the direct air route between Tupelo and Florence. Straight-line distance: 167.17 mi (269.03 km).
#1 Tupelo
City in and county seat of Lee County, Mississippi, United States
| Population | 38,303 |
| Coordinates | 34.2580700, -88.7046400 |
| Altitude | 85 |
| Country | United States |
#2 Florence
Town in Mississippi, US
| Population | 4,531 |
| Coordinates | 32.1534800, -90.1312000 |
| Altitude | 95 |
| Country | United States |
End: Florence (-90.1312, 32.15348)
Estimated Travel Time
Distance: 326 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 06h 44m |
| 40 mph (64.37 km/h) | 05h 03m |
| 50 mph (80.47 km/h) | 04h 02m |
| 60 mph (96.56 km/h) | 03h 22m |
| 70 mph (112.65 km/h) | 02h 53m |
| 80 mph (129 km/h) | 02h 31m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $27.08 | $54.15 |
| Mid-grade | $4.26 | $30.45 | $60.90 |
| Premium | $4.63 | $33.07 | $66.14 |
| Diesel | $5.42 | $38.72 | $77.43 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.