How far is Thermopolis, WY from Cheyenne, WY?
Fastest route
The journey from Thermopolis, Wyoming 82443 to Cheyenne, Wyoming is approximately 308 miles (496 kilometers) long and takes around 4 hours and 42 minutes. The fastest route, considering current traffic conditions, is via US-20 E and I-25 S.
Directions
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Start by getting on I-25 S/US-87 S in Natrona County from US-20 E.
- 🚗 Take S 6th St south toward Warren St.
- 🚗 Pass by O'Reilly Auto Parts (on the right in 0.3 mi).
- 🚗 Continue onto US-20 E/Shoshoni St.
- 🚗 Follow the signs to stay on US-20 E.
- 🚗 Turn left onto US-20 E/US-26 E/E 2 St/2nd St.
- 🚗 Continue to follow US-20 E/US-26 E.
- 🚗 Turn left onto US-20 E/US-26.
- 🚗 Use the right lane to merge onto I-25 S/US-87 S via the ramp to Casper/Cheyenne.
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Follow I-25 S to Randall Ave in Laramie County. Take exit 11 from I-25 S.
- 🚗 Continue on I-25 S.
- 🚗 Use the right two lanes to take exit 11 for Randall Ave toward Pershing Blvd.
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Continue on Randall Ave. Drive to W 24th St in Cheyenne.
- 🚗 Turn left onto Randall Ave.
- 🚗 Continue straight to stay on Randall Ave.
- 🚗 Slight right onto Pioneer Ave.
- 🚗 Arrive at W 24th St in Cheyenne.
Tips & Suggestions
- 🛣️ Plan your journey in advance and consider checking for any road closures or construction updates before you start.
- ⛽ Make sure your vehicle is fueled up before hitting the road, as there might be stretches with limited gas stations.
- 🚗 Take regular breaks during the journey to stretch your legs and stay refreshed.
- 🍴 Pack some snacks and drinks for the trip, especially if you don't plan on making many stops.
- 📱 Use a navigation app or GPS device to stay on track and receive real-time traffic updates.
- 🚦 Observe traffic laws and speed limits for a safe and hassle-free journey.
- 🚘 Keep some spare change or a card handy for toll roads, if applicable.
- 🌧️ Check the weather forecast before you depart to ensure you're prepared for any adverse conditions.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 55m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Converse County, Wyoming, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Thermopolis and Cheyenne.
Turn-by-Turn Driving Directions
Step-by-step road directions between Thermopolis and Cheyenne.
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1
Start on South 6th Street
2765 ft · 1 min · South 6th Street
-
2
Turn right onto Shoshoni Street
1.4 km · 2 min · Shoshoni Street
-
3
Continue straight
31 mi · 36 min
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4
Turn left onto East 2nd Street
33.1 mi · 38 min · East 2nd Street
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5
Continue on West US Highway 20-26
60.7 mi · 1 hr 9 min · West US Highway 20-26
-
6
Turn left
2.7 mi · 3 min
-
7
Take the exit right
62.8 mi · 1 hr 6 min
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8
Continue straight
34.1 mi · 32 min
-
9
Continue on Cheyenne
75.6 mi · 1 hr 11 min
-
10
Continue straight
4 mi · 4 min
-
11
Take the exit slight right toward I 25 Business, US 85 South: Central Avenue, Warren Gate 5
1363 ft · 35 sec
-
12
Turn left onto Central Avenue
1.3 km · 1 min · Central Avenue
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13
Continue on Central Avenue
1.6 mi · 2 min · Central Avenue
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14
Turn right onto West 24th Street
122 m · 11 sec · West 24th Street
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15
Arrive at your destination
0 m · 1 sec · West 24th Street
Car Route Details
A richer read on the saved driving route between Thermopolis and Cheyenne.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
West US Highway 20-26
Continue on Cheyenne
75.6 mi · 01h 11m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Thermopolis and Mostly Sunny near Cheyenne.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Thermopolis to Cheyenne?
The road trip is about 308 miles (495.7 km) and usually takes 04h 55m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Glenrock is a useful midpoint, sitting about 153.9 miles from Thermopolis and 154.2 miles from Cheyenne.
How much longer is the road route than the straight-line distance?
The direct path is about 244.8 miles (393.9 km), while the road route adds roughly 63.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM MDT. If you want a more comfortable same-day return, try to leave by 7:08 AM MDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.32 one way or $84.63 round trip. Estimated CO2 is about 96.6 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Thermopolis and Mostly Sunny near Cheyenne.
Stop Ideas Near Glenrock
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Glenrock.
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Flight Path Map
This map shows the direct air route between Thermopolis and Cheyenne. Straight-line distance: 244.78 mi (393.93 km).
#1 Thermopolis
Town of the United States
| Population | 2,770 |
| Coordinates | 43.6460700, -108.2120400 |
| Altitude | 1320 |
| Country | United States |
#2 Cheyenne
The most populous city in Laramie County, Wyoming.
| Population | 64,742 |
| Coordinates | 41.1399800, -104.8202500 |
| Altitude | 1856 |
| Country | United States |
End: West 24th Street (-104.820107, 41.139762)
Estimated Travel Time
Distance: 496 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 15m |
| 40 mph (64.37 km/h) | 07h 42m |
| 50 mph (80.47 km/h) | 06h 09m |
| 60 mph (96.56 km/h) | 05h 08m |
| 70 mph (112.65 km/h) | 04h 24m |
| 80 mph (129 km/h) | 03h 50m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.89 | $42.32 | $84.63 |
| Mid-grade | $4.23 | $45.99 | $91.98 |
| Premium | $4.55 | $49.45 | $98.90 |
| Diesel | $5.41 | $58.83 | $117.66 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Wyoming · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.