How far is South San Francisco, CA from San Diego, CA?
The driving distance from South San Francisco, CA to San Diego, CA is about 509.9 miles (820.6 km), with a travel time of about 08h 21m by car.
- The straight-line flight distance is about 451.6 miles (726.8 km).
- For a round trip, plan for roughly 16h 43m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM PDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 08h 21m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Place in Kern County California
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between South San Francisco and San Diego.
Turn-by-Turn Driving Directions
Step-by-step road directions between South San Francisco and San Diego.
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1
Start on Airport Boulevard
112 m · 16 sec · Airport Boulevard
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2
Turn left onto Miller Avenue
75 m · 12 sec · Miller Avenue
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3
Turn right onto Cypress Avenue
111 m · 17 sec · Cypress Avenue
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4
Turn right onto Lux Avenue
65 m · 12 sec · Lux Avenue
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5
Turn right onto Airport Boulevard
2662 ft · 59 sec · Airport Boulevard
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6
Continue on Produce Avenue
1386 ft · 27 sec · Produce Avenue
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7
Take the ramp straight toward US 101 South: San Jose
802 ft · 22 sec
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8
Merge slight left onto Bayshore Freeway
2286 ft · 30 sec · Bayshore Freeway
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9
Keep slight left to continue on Bayshore Freeway
25 mi · 29 min · Bayshore Freeway
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10
Keep slight left to continue on Bayshore Freeway
42.4 mi · 49 min · Bayshore Freeway
-
11
Take the exit slight right toward CA 152 East: 10th Street, Pacheco Pass Road
1539 ft · 40 sec
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12
Turn left onto East 10th Street
108 m · 13 sec · East 10th Street
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13
Continue on Pacheco Pass Highway
40.6 mi · 50 min · Pacheco Pass Highway
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14
Take the exit slight right toward I 5: Los Angeles
3148 ft · 1 min
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15
Merge slight left onto Westside Freeway
181.1 mi · 3 hr 14 min · Westside Freeway
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16
Keep slight right
58.4 mi · 1 hr 7 min
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17
Keep slight left to continue on Golden State Freeway
4.1 mi · 5 min · Golden State Freeway
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18
Keep slight right to continue on I 405 South
1354 ft · 18 sec
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19
Keep slight left
24.7 mi · 29 min
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20
Keep slight left to continue on Golden State Freeway
1.3 mi · 2 min · Golden State Freeway
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21
Merge slight left onto Santa Ana Freeway
25.7 mi · 30 min · Santa Ana Freeway
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22
Keep slight right to continue on Santa Ana Freeway
1241 ft · 16 sec · Santa Ana Freeway
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23
Take the exit slight right toward Broadway, Main Street, Santa Ana
1.3 km · 57 sec
-
24
Keep slight left
788 ft · 10 sec
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25
Keep slight left to continue on I 5 South
981 ft · 13 sec
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26
Merge slight left onto Santa Ana Freeway
1.3 km · 54 sec · Santa Ana Freeway
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27
Keep slight right to continue on Santa Ana Freeway
1.2 km · 52 sec · Santa Ana Freeway
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28
Keep slight right to continue on Santa Ana Freeway
1.2 mi · 1 min · Santa Ana Freeway
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29
Take the exit slight right toward Newport Avenue
1.2 km · 1 min
-
30
Turn right onto Newport Avenue
1943 ft · 44 sec · Newport Avenue
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31
Turn left onto Walnut Avenue
2.2 mi · 4 min · Walnut Avenue
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32
Turn left onto Jamboree Road
2595 ft · 38 sec · Jamboree Road
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33
Take the exit slight right toward I 5 South
1479 ft · 21 sec
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34
Merge slight left onto Santa Ana Freeway
5.5 mi · 6 min · Santa Ana Freeway
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35
Keep slight left to continue on Santa Ana Freeway
1.3 km · 56 sec · Santa Ana Freeway
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36
Merge slight right onto San Diego Freeway
76.5 mi · 1 hr 29 min · San Diego Freeway
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37
Take the exit slight right toward Front Street, Civic Center, 2nd Avenue
1164 ft · 28 sec
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38
Keep slight right to continue on Front Street, Civic Center
592 ft · 15 sec
-
39
Continue on Front Street
2662 ft · 2 min · Front Street
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40
Arrive at your destination
0 m · 1 sec · Front Street
Car Route Details
A richer read on the saved driving route between South San Francisco and San Diego.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Westside Freeway
Merge slight left onto Westside Freeway
181 mi · 03h 14m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Sunny leaving South San Francisco and Mostly Sunny near San Diego.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from South San Francisco to San Diego?
The road trip is about 509.9 miles (820.6 km) and usually takes 08h 21m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Buttonwillow is a useful midpoint, sitting about 249 miles from South San Francisco and 260.9 miles from San Diego.
How much longer is the road route than the straight-line distance?
The direct path is about 451.6 miles (726.8 km), while the road route adds roughly 58.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM PDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $103.78 one way or $207.57 round trip. Estimated CO2 is about 159.9 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around South San Francisco and Mostly Sunny near San Diego.
Stop Ideas Near Buttonwillow
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Buttonwillow.
Wasco station
Bakersfield
Corcoran station
Kettleman City, California
Flight Path Map
This map shows the direct air route between South San Francisco and San Diego. Straight-line distance: 451.61 mi (726.8 km).
#1 South San Francisco
The most populous city in San Mateo County, California.
| Population | 66,558 |
| Coordinates | 37.6546600, -122.4077500 |
| Altitude | 4 |
| Country | United States |
#2 San Diego
The eighth most populous city in the United States and the center of the San Diego metropolitan area.
| Population | 1,422,420 |
| Coordinates | 32.7157100, -117.1647200 |
| Altitude | 20 |
| Country | United States |
End: Front Street (-117.164717, 32.71571)
Estimated Travel Time
Distance: 821 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 16h 59m |
| 40 mph (64.37 km/h) | 12h 44m |
| 50 mph (80.47 km/h) | 10h 11m |
| 60 mph (96.56 km/h) | 08h 29m |
| 70 mph (112.65 km/h) | 07h 17m |
| 80 mph (129 km/h) | 06h 21m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $5.77 | $103.78 | $207.57 |
| Mid-grade | $6.07 | $109.13 | $218.25 |
| Premium | $6.24 | $112.31 | $224.62 |
| Diesel | $7.57 | $136.13 | $272.26 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in California · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.