How far is San Antonio, TX from Henrietta, TX?
The driving distance from San Antonio, TX to Henrietta, TX is about 321 miles (516.6 km), with a travel time of about 06h 27m by car.
- The straight-line flight distance is about 304 miles (489.3 km).
- For a round trip, plan for roughly 12h 55m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 27m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Hamilton County, Texas, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Cloudy
Partly Sunny then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between San Antonio and Henrietta.
Turn-by-Turn Driving Directions
Step-by-step road directions between San Antonio and Henrietta.
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1
Start on Dolorosa Street
44 m · 5 sec · Dolorosa Street
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2
Continue on West Market Street
1893 ft · 42 sec · West Market Street
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3
Continue on East Market Street
2143 ft · 46 sec · East Market Street
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4
Turn left
111 m · 13 sec
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5
Turn straight onto East Commerce Street
66 m · 13 sec · East Commerce Street
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6
Take the ramp sharp left toward US 281 North, I 37 North
1159 ft · 28 sec
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7
Merge slight left onto William J Bordelon Freeway
1.5 km · 1 min · William J Bordelon Freeway
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8
Continue on McAllister Freeway
14.9 mi · 18 min · McAllister Freeway
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9
Keep slight left to continue on US 281 HOV Lane
2.9 mi · 3 min · US 281 HOV Lane
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10
Merge slight right
100.6 mi · 1 hr 59 min
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11
At the end of the road, turn left onto South Key Avenue
1.6 mi · 3 min · South Key Avenue
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12
Continue on North US Highway 281
965 ft · 15 sec · North US Highway 281
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13
Keep slight right to continue on North US Highway 281
42.9 mi · 49 min · North US Highway 281
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14
Continue on South Rice Street
2.3 mi · 3 min · South Rice Street
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15
Continue on North US Highway 281
19 mi · 20 min · North US Highway 281
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16
Continue on South Walnut Street
2995 ft · 43 sec · South Walnut Street
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17
At the end of the road, turn left onto North 2nd Street
2039 ft · 26 sec · North 2nd Street
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18
Continue on North US Highway 281
18 mi · 20 min · North US Highway 281
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19
Continue on East Road
1.1 mi · 2 min · East Road
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20
Continue on Morgan Mill Road
39.9 mi · 44 min · Morgan Mill Road
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21
Continue on South Oak Avenue
2.9 mi · 3 min · South Oak Avenue
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22
Continue on North US Highway 281
14.9 mi · 17 min · North US Highway 281
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23
Continue on South Benson Street
15.5 mi · 19 min · South Benson Street
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24
Turn right onto State Highway 148
40.2 mi · 1 hr · State Highway 148
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25
Continue on South Graham Street
1.4 km · 1 min · South Graham Street
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26
Turn right onto West Omega Street
613 ft · 25 sec · West Omega Street
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27
Turn left onto South Bridge Street
930 ft · 21 sec · South Bridge Street
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28
Turn right onto East Wichita Street
1 m · 1 sec · East Wichita Street
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29
Arrive at your destination
0 m · 1 sec · East Wichita Street
Car Route Details
A richer read on the saved driving route between San Antonio and Henrietta.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
US 281 HOV Lane
Merge slight right
101 mi · 01h 59m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Mostly Cloudy leaving San Antonio and Partly Sunny then Chance Showers And Thunderstorms near Henrietta.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from San Antonio to Henrietta?
The road trip is about 321 miles (516.6 km) and usually takes 06h 27m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Hamilton is a useful midpoint, sitting about 160.9 miles from San Antonio and 160.1 miles from Henrietta.
How much longer is the road route than the straight-line distance?
The direct path is about 304 miles (489.3 km), while the road route adds roughly 17 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.82 one way or $85.63 round trip. Estimated CO2 is about 100.7 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Cloudy around San Antonio and Partly Sunny then Chance Showers And Thunderstorms near Henrietta.
Stop Ideas Near Hamilton
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Hamilton.
Fort Hood, Texas
Killeen, Texas
McGregor
Waco, TX
Flight Path Map
This map shows the direct air route between San Antonio and Henrietta. Straight-line distance: 304.05 mi (489.32 km).
#1 San Antonio
The seventh most populous city in the United States and the center of the San Antonio metropolitan area.
| Population | 1,567,118 |
| Coordinates | 29.4241200, -98.4936300 |
| Altitude | 198 |
| Country | United States |
#2 Henrietta
City in Texas, USA
| Population | 3,133 |
| Coordinates | 33.8173200, -98.1953200 |
| Altitude | 278 |
| Country | United States |
End: Henrietta (-98.19532, 33.81732)
Estimated Travel Time
Distance: 517 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 41m |
| 40 mph (64.37 km/h) | 08h 01m |
| 50 mph (80.47 km/h) | 06h 25m |
| 60 mph (96.56 km/h) | 05h 21m |
| 70 mph (112.65 km/h) | 04h 35m |
| 80 mph (129 km/h) | 04h 00m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $42.82 | $85.63 |
| Mid-grade | $4.25 | $48.18 | $96.35 |
| Premium | $4.59 | $52.02 | $104.03 |
| Diesel | $3.99 | $45.24 | $90.48 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.