How far is Saint John, MO from Cape Girardeau, MO?
The driving distance from Saint John, MO to Cape Girardeau, MO is about 131.1 miles (211 km), with a travel time of about 02h 05m by car.
- The straight-line flight distance is about 107.3 miles (172.7 km).
- For a round trip, plan for roughly 04h 10m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 05m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Sainte Genevieve County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Saint John and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint John and Cape Girardeau.
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1
Start on Mavis Place
99 m · 20 sec · Mavis Place
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2
Turn left onto Marshall Road
1922 ft · 1 min · Marshall Road
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3
At the end of the road, turn left onto Saint Charles Rock Road
2733 ft · 58 sec · Saint Charles Rock Road
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4
Take the ramp slight right toward I 170 South
1151 ft · 16 sec
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5
Merge slight left onto Inner Belt Expressway
5.4 mi · 7 min · Inner Belt Expressway
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6
Keep slight left to continue on I 64 East, US 40 East: Saint Louis
2901 ft · 46 sec
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7
Merge slight left onto Daniel Boone Expressway
1.4 mi · 2 min · Daniel Boone Expressway
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8
Take the exit slight right toward McCausland Avenue
1052 ft · 26 sec
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9
Turn right onto McCausland Avenue
1.5 mi · 2 min · McCausland Avenue
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10
Continue on Ellendale Avenue
2852 ft · 56 sec · Ellendale Avenue
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11
Continue on Wellington Avenue
1740 ft · 35 sec · Wellington Avenue
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12
Continue on Wabash Avenue
1709 ft · 34 sec · Wabash Avenue
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13
Turn right onto Lansdowne Avenue
651 ft · 25 sec · Lansdowne Avenue
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14
Turn left onto River Des Peres Boulevard
1878 ft · 40 sec · River Des Peres Boulevard
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15
Turn right onto Weil Avenue
88 m · 15 sec · Weil Avenue
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16
Continue on Weil Avenue
605 ft · 21 sec · Weil Avenue
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17
At the end of the road, turn right onto Chippewa Street
599 ft · 17 sec · Chippewa Street
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18
Continue on Watson Road
801 ft · 19 sec · Watson Road
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19
Turn left onto Mackenzie Road
3.3 mi · 7 min · Mackenzie Road
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20
Turn straight onto Reavis Barracks Road
1.1 km · 1 min · Reavis Barracks Road
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21
Take the ramp slight right toward I 55 South
997 ft · 14 sec
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22
Merge slight left
99.2 mi · 1 hr 47 min
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23
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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24
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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25
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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26
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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27
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Saint John and Cape Girardeau.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
I 55 South
Merge slight left
99.2 mi · 01h 47m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Showers And Thunderstorms Likely leaving Saint John and Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Saint John to Cape Girardeau?
The road trip is about 131.1 miles (211 km) and usually takes 02h 05m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Bloomsdale is a useful midpoint, sitting about 60.9 miles from Saint John and 70.2 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 107.3 miles (172.7 km), while the road route adds roughly 23.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 2:20 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $17.46 one way or $34.92 round trip. Estimated CO2 is about 41.1 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely around Saint John and Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Bloomsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Bloomsdale.
Kirkwood
Gateway Transportation Center
Du Quoin
Carbondale station
Flight Path Map
This map shows the direct air route between Saint John and Cape Girardeau. Straight-line distance: 107.28 mi (172.65 km).
#1 Saint John
City in Missouri, USA
| Population | 6,319 |
| Coordinates | 38.7148400, -90.3462700 |
| Altitude | 196 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 211 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 04h 22m |
| 40 mph (64.37 km/h) | 03h 16m |
| 50 mph (80.47 km/h) | 02h 37m |
| 60 mph (96.56 km/h) | 02h 11m |
| 70 mph (112.65 km/h) | 01h 52m |
| 80 mph (129 km/h) | 01h 38m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $17.46 | $34.92 |
| Mid-grade | $4.25 | $19.69 | $39.38 |
| Premium | $4.65 | $21.55 | $43.10 |
| Diesel | $5.30 | $24.56 | $49.12 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 29, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.