How far is Saint Charles, MO from Maysville, MO?
The driving distance from Saint Charles, MO to Maysville, MO is about 267.6 miles (430.6 km), with a travel time of about 05h 24m by car.
- The straight-line flight distance is about 221 miles (355.6 km).
- For a round trip, plan for roughly 10h 48m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Shelby County, Missouri
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Saint Charles and Maysville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Charles and Maysville.
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1
Start on North Second Street
1551 ft · 1 min · North Second Street
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2
Turn right onto First Capitol Drive
1.4 km · 2 min · First Capitol Drive
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3
Turn left onto First Capitol Drive
1.5 km · 2 min · First Capitol Drive
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4
Take the ramp slight right toward I 70 West
1018 ft · 14 sec
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5
Merge slight left
17.5 mi · 22 min
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6
Take the exit slight right toward US 61 North: Hannibal
2234 ft · 48 sec
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7
Merge slight left onto Avenue of the Saints
73.3 mi · 1 hr 27 min · Avenue of the Saints
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8
Take the exit slight left
76 m · 15 sec
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9
Turn left onto Paris Gravel Road
2645 ft · 1 min · Paris Gravel Road
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10
Keep slight right to continue on County Road 422
85 m · 9 sec · County Road 422
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11
Turn right onto Veterans Road
2.2 mi · 4 min · Veterans Road
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12
Take the ramp left toward US 36 West, MO 110 West: Monroe City
1226 ft · 16 sec
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13
Merge slight left onto V.F.W. Memorial Highway
5.8 mi · 7 min · V.F.W. Memorial Highway
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14
Continue on Chicago-Kansas City Expressway
156.2 mi · 3 hr 1 min · Chicago-Kansas City Expressway
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15
Turn right
8.9 mi · 16 min
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16
Turn left onto West Main Street
712 ft · 14 sec · West Main Street
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17
Arrive at your destination
0 m · 1 sec · West Main Street
Car Route Details
A richer read on the saved driving route between Saint Charles and Maysville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Chicago-Kansas City Expressway
Continue on Chicago-Kansas City Expressway
156 mi · 03h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Saint Charles and Chance Showers And Thunderstorms near Maysville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Saint Charles to Maysville?
The road trip is about 267.6 miles (430.6 km) and usually takes 05h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Shelbina is a useful midpoint, sitting about 133.6 miles from Saint Charles and 134 miles from Maysville.
How much longer is the road route than the straight-line distance?
The direct path is about 221 miles (355.6 km), while the road route adds roughly 46.6 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:12 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $35.60 one way or $71.20 round trip. Estimated CO2 is about 83.9 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Saint Charles and Chance Showers And Thunderstorms near Maysville.
Stop Ideas Near Shelbina
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Shelbina.
La Plata
Quincy
Flight Path Map
This map shows the direct air route between Saint Charles and Maysville. Straight-line distance: 220.97 mi (355.62 km).
#1 Saint Charles
A city in St.
| Population | 71,761 |
| Coordinates | 38.7839400, -90.4812300 |
| Altitude | 147 |
| Country | United States |
#2 Maysville
City in DeKalb County, Missouri, United States
| Population | 1,073 |
| Coordinates | 39.8891700, -94.3619000 |
| Altitude | 296 |
| Country | United States |
End: Maysville (-94.3619, 39.88917)
Estimated Travel Time
Distance: 431 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 54m |
| 40 mph (64.37 km/h) | 06h 41m |
| 50 mph (80.47 km/h) | 05h 21m |
| 60 mph (96.56 km/h) | 04h 27m |
| 70 mph (112.65 km/h) | 03h 49m |
| 80 mph (129 km/h) | 03h 20m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $35.60 | $71.20 |
| Mid-grade | $4.25 | $40.15 | $80.30 |
| Premium | $4.65 | $43.93 | $87.87 |
| Diesel | $5.30 | $50.07 | $100.14 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.