How far is Saint Charles, MO from East Prairie, MO?
The driving distance from Saint Charles, MO to East Prairie, MO is about 175.8 miles (282.9 km), with a travel time of about 03h 19m by car.
- The straight-line flight distance is about 150.9 miles (242.8 km).
- For a round trip, plan for roughly 06h 38m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 19m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Saint Charles and East Prairie.
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Charles and East Prairie.
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1
Start on North Second Street
949 ft · 38 sec · North Second Street
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2
Turn right onto Jefferson Street
1093 ft · 45 sec · Jefferson Street
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3
Turn left onto South Fifth Street
1.1 mi · 3 min · South Fifth Street
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4
Take the ramp slight left toward I 70 East
1019 ft · 14 sec
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5
Merge slight left
2.7 mi · 3 min
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6
Take the exit slight right toward I 270: Chicago, Memphis
872 ft · 12 sec
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7
Keep slight right to continue on I 270 South: Memphis
2339 ft · 33 sec
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8
Continue on I 270 South: Memphis
723 ft · 10 sec
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9
Merge slight left
19 mi · 24 min
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10
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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11
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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12
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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13
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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14
Continue on Police Officer Steven Jarvis Memorial Highway
127.1 mi · 2 hr 16 min · Police Officer Steven Jarvis Memorial Highway
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15
Take the exit slight right toward I 57 North, US 60 East: Chicago
1264 ft · 31 sec
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16
Merge slight left
10.3 mi · 11 min
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17
Take the exit slight right toward I 57 Business North, MO 105: Charleston, East Prairie
1111 ft · 27 sec
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18
Turn right onto South Main Street
9.4 mi · 13 min · South Main Street
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19
Turn left onto North Washington Street
1650 ft · 38 sec · North Washington Street
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20
Turn left onto East Main Street
26 m · 4 sec · East Main Street
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21
Arrive at your destination
0 m · 1 sec · East Main Street
Car Route Details
A richer read on the saved driving route between Saint Charles and East Prairie.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
127 mi · 02h 16m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Saint Charles and Sunny near East Prairie.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Saint Charles to East Prairie?
The road trip is about 175.8 miles (282.9 km) and usually takes 03h 19m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Perryville is a useful midpoint, sitting about 88 miles from Saint Charles and 87.9 miles from East Prairie.
How much longer is the road route than the straight-line distance?
The direct path is about 150.9 miles (242.8 km), while the road route adds roughly 24.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:22 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $23.38 one way or $46.76 round trip. Estimated CO2 is about 55.1 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Saint Charles and Sunny near East Prairie.
Stop Ideas Near Perryville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Perryville.
Carbondale station
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Flight Path Map
This map shows the direct air route between Saint Charles and East Prairie. Straight-line distance: 150.84 mi (242.76 km).
#1 Saint Charles
A city in St.
| Population | 71,761 |
| Coordinates | 38.7839400, -90.4812300 |
| Altitude | 147 |
| Country | United States |
#2 East Prairie
City in Mississippi County, Missouri, United States
| Population | 2,924 |
| Coordinates | 36.7797800, -89.3856300 |
| Altitude | 93 |
| Country | United States |
End: East Prairie (-89.38563, 36.77978)
Estimated Travel Time
Distance: 283 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 51m |
| 40 mph (64.37 km/h) | 04h 23m |
| 50 mph (80.47 km/h) | 03h 30m |
| 60 mph (96.56 km/h) | 02h 55m |
| 70 mph (112.65 km/h) | 02h 30m |
| 80 mph (129 km/h) | 02h 11m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $23.38 | $46.76 |
| Mid-grade | $4.25 | $26.37 | $52.74 |
| Premium | $4.65 | $28.85 | $57.71 |
| Diesel | $5.30 | $32.88 | $65.77 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.