How far is Republic, MO from Cape Girardeau, MO?
The driving distance from Republic, MO to Cape Girardeau, MO is about 277.8 miles (447 km), with a travel time of about 04h 24m by car.
- The straight-line flight distance is about 218.3 miles (351.4 km).
- For a round trip, plan for roughly 08h 49m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 24m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny then Slight Chance Showers And Thunderstorms
Showers And Thunderstorms then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Republic and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Republic and Cape Girardeau.
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1
Start on East Grant Street
27 m · 6 sec · East Grant Street
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2
Turn right onto North Main Avenue
2345 ft · 1 min · North Main Avenue
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3
Turn right
1 mi · 2 min
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4
Turn left
4.1 mi · 6 min
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5
Take the ramp slight right toward US 60 East: Rogersville
1731 ft · 37 sec
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6
Merge slight left onto James River Freeway
92.1 mi · 1 hr 48 min · James River Freeway
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7
Keep slight left to continue on US 60 East: Mountain View, Poplar Bluff
90.4 mi · 1 hr 47 min
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8
Keep slight right
4.8 mi · 6 min
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9
Turn straight onto North Westwood Boulevard
823 ft · 14 sec · North Westwood Boulevard
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10
Turn slight left
84 m · 12 sec
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11
Turn left
756 ft · 16 sec
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12
Take the ramp right
1102 ft · 27 sec
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13
Merge slight left
51 mi · 59 min
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14
Take the exit slight right toward I 55 North: Saint Louis
1793 ft · 44 sec
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15
Merge slight left
27.4 mi · 29 min
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16
Keep slight right to continue on US 61, I 55 Business: Cape Girardeau
2 mi · 3 min
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17
Turn right onto Shawnee Parkway
1.6 mi · 3 min · Shawnee Parkway
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18
Turn left onto South Sprigg Street
1.3 km · 2 min · South Sprigg Street
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19
Turn right onto Broadway Street
2497 ft · 51 sec · Broadway Street
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20
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Republic and Cape Girardeau.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
James River Freeway
Merge slight left onto James River Freeway
92.1 mi · 01h 48m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny then Slight Chance Showers And Thunderstorms leaving Republic and Showers And Thunderstorms then Chance Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Republic to Cape Girardeau?
The road trip is about 277.8 miles (447 km) and usually takes 04h 24m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Winona is a useful midpoint, sitting about 138.6 miles from Republic and 139.2 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 218.3 miles (351.4 km), while the road route adds roughly 59.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:10 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $36.96 one way or $73.91 round trip. Estimated CO2 is about 87.1 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny then Slight Chance Showers And Thunderstorms around Republic and Showers And Thunderstorms then Chance Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Winona
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Winona.
Poplar Bluff
Walnut Ridge
Flight Path Map
This map shows the direct air route between Republic and Cape Girardeau. Straight-line distance: 218.37 mi (351.44 km).
#1 Republic
Form of government where the head of state is elected
| Population | 17,481 |
| Coordinates | 37.1200500, -93.4801900 |
| Altitude | 399 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 447 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 15m |
| 40 mph (64.37 km/h) | 06h 56m |
| 50 mph (80.47 km/h) | 05h 33m |
| 60 mph (96.56 km/h) | 04h 37m |
| 70 mph (112.65 km/h) | 03h 58m |
| 80 mph (129 km/h) | 03h 27m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $36.96 | $73.91 |
| Mid-grade | $4.25 | $41.68 | $83.36 |
| Premium | $4.65 | $45.61 | $91.22 |
| Diesel | $5.30 | $51.98 | $103.96 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 25, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.