How far is Plymouth, NC from Winston-Salem, NC?
The driving distance from Plymouth, NC to Winston-Salem, NC is about 225.6 miles (363 km), with a travel time of about 03h 32m by car.
- The straight-line flight distance is about 196.1 miles (315.6 km).
- For a round trip, plan for roughly 07h 04m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 32m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Wake County, North Carolina, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers then Chance Showers And Thunderstorms
Chance Rain Showers
Driving Route Map
The map below follows the saved road route between Plymouth and Winston-Salem.
Turn-by-Turn Driving Directions
Step-by-step road directions between Plymouth and Winston-Salem.
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1
Start on the route
11 m · 5 sec
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2
Turn right onto East Main Street
621 ft · 30 sec · East Main Street
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3
Turn left onto Washington Street
3104 ft · 1 min · Washington Street
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4
Turn right onto U.S. Highway 64 West
2 mi · 3 min · U.S. Highway 64 West
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5
Continue on US Highway 64 West
17.7 mi · 24 min · US Highway 64 West
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6
Turn left
1.8 mi · 2 min
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7
Continue straight
56.5 mi · 1 hr 1 min
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8
Continue straight
27.8 mi · 30 min
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9
Take the exit slight right toward Rolesville Road
1173 ft · 29 sec
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10
Keep slight right to continue on Rolesville Road
94 m · 8 sec
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11
Turn right onto Rolesville Road
2.4 mi · 4 min · Rolesville Road
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12
Turn sharp left onto Marks Creek Road
2050 ft · 39 sec · Marks Creek Road
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13
Turn right onto Horton Road
2310 ft · 44 sec · Horton Road
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14
Turn right onto Buffaloe Road
3.8 mi · 7 min · Buffaloe Road
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15
Take the ramp right
1943 ft · 24 sec
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16
Merge slight left onto Northern Wake Expressway
15.4 mi · 17 min · Northern Wake Expressway
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17
Take the exit slight right toward US 70 West: Durham
2972 ft · 1 min
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18
Merge slight left onto Glenwood Avenue
1.9 mi · 3 min · Glenwood Avenue
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19
Continue on New Raleigh Highway
2.5 mi · 4 min · New Raleigh Highway
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20
Continue on South Miami Boulevard
9.3 mi · 12 min · South Miami Boulevard
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21
Keep slight left
42.3 mi · 49 min
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22
Keep slight right
7.7 mi · 9 min
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23
Keep slight right
12.6 mi · 15 min
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24
Keep slight right to continue on Salem Parkway
13.4 mi · 16 min · Salem Parkway
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25
Take the exit slight right toward Main Street
1174 ft · 29 sec
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26
Turn slight right onto South Main Street
2161 ft · 44 sec · South Main Street
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27
Arrive at your destination
0 m · 1 sec · North Main Street
Car Route Details
A richer read on the saved driving route between Plymouth and Winston-Salem.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
US Highway 64 West
Continue straight
56.5 mi · 01h 01m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Slight Chance Rain Showers then Chance Showers And Thunderstorms leaving Plymouth and Chance Rain Showers near Winston-Salem.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Plymouth to Winston-Salem?
The road trip is about 225.6 miles (363 km) and usually takes 03h 32m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Knightdale is a useful midpoint, sitting about 110.1 miles from Plymouth and 115.5 miles from Winston-Salem.
How much longer is the road route than the straight-line distance?
The direct path is about 196.1 miles (315.6 km), while the road route adds roughly 29.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 9:56 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $31.53 one way or $63.06 round trip. Estimated CO2 is about 70.7 kg one way.
What should you check before leaving?
Before you leave, expect Slight Chance Rain Showers then Chance Showers And Thunderstorms around Plymouth and Chance Rain Showers near Winston-Salem.
Stop Ideas Near Knightdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Town Hall Burger and Beer
Garner Town Hall
Clayton Utilities
City Of Raleigh Fleet Services
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Knightdale.
Raleigh Union Station
North Carolina State Fair station
Cary
Selma–Smithfield
Flight Path Map
This map shows the direct air route between Plymouth and Winston-Salem. Straight-line distance: 196.09 mi (315.58 km).
#1 Plymouth
Town in North Carolina, United States
| Population | 3,332 |
| Coordinates | 35.8668300, -76.7485600 |
| Altitude | 4 |
| Country | United States |
#2 Winston-Salem
The fifth most populous city in North Carolina.
| Population | 248,112 |
| Coordinates | 36.0998600, -80.2442200 |
| Altitude | 293 |
| Country | United States |
End: North Main Street (-80.244255, 36.099856)
Estimated Travel Time
Distance: 363 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 30m |
| 40 mph (64.37 km/h) | 05h 38m |
| 50 mph (80.47 km/h) | 04h 30m |
| 60 mph (96.56 km/h) | 03h 45m |
| 70 mph (112.65 km/h) | 03h 13m |
| 80 mph (129 km/h) | 02h 48m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.96 | $31.53 | $63.06 |
| Mid-grade | $4.43 | $35.25 | $70.51 |
| Premium | $4.78 | $38.03 | $76.07 |
| Diesel | $5.62 | $44.77 | $89.53 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in North Carolina · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.