How far is O'Fallon, MO from Cape Girardeau, MO?
The driving distance from O'Fallon, MO to Cape Girardeau, MO is about 141.5 miles (227.7 km), with a travel time of about 02h 11m by car.
- The straight-line flight distance is about 122.2 miles (196.7 km).
- For a round trip, plan for roughly 04h 23m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 11m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Sainte Genevieve County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between O'Fallon and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon and Cape Girardeau.
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1
Start on the route
8 m · 7 sec
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2
Turn left onto South Main Street
3116 ft · 2 min · South Main Street
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3
Turn left onto Drennen Parkway
1.4 km · 1 min · Drennen Parkway
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4
Take the ramp slight left toward I 70 East: Saint Louis
133 m · 6 sec
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5
Merge slight left
13.5 mi · 17 min
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6
Take the exit slight right toward I 270: Chicago, Memphis
872 ft · 12 sec
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7
Keep slight right to continue on I 270 South: Memphis
2339 ft · 33 sec
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8
Continue on I 270 South: Memphis
723 ft · 10 sec
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9
Merge slight left
19 mi · 24 min
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10
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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11
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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12
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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13
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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14
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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15
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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16
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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17
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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18
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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19
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between O'Fallon and Cape Girardeau.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Showers And Thunderstorms leaving O'Fallon and Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from O'Fallon to Cape Girardeau?
The road trip is about 141.5 miles (227.7 km) and usually takes 02h 11m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
Bloomsdale is a useful midpoint, sitting about 69.1 miles from O'Fallon and 72.5 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 122.2 miles (196.7 km), while the road route adds roughly 19.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 2:06 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $18.82 one way or $37.63 round trip. Estimated CO2 is about 44.3 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around O'Fallon and Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near Bloomsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Bloomsdale.
Kirkwood
Gateway Transportation Center
Du Quoin
Carbondale station
Flight Path Map
This map shows the direct air route between O'Fallon and Cape Girardeau. Straight-line distance: 122.24 mi (196.72 km).
#1 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 228 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 04h 42m |
| 40 mph (64.37 km/h) | 03h 32m |
| 50 mph (80.47 km/h) | 02h 49m |
| 60 mph (96.56 km/h) | 02h 21m |
| 70 mph (112.65 km/h) | 02h 01m |
| 80 mph (129 km/h) | 01h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $18.82 | $37.63 |
| Mid-grade | $4.25 | $21.22 | $42.44 |
| Premium | $4.65 | $23.22 | $46.45 |
| Diesel | $5.30 | $26.47 | $52.93 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.