How far is Niles, IL from Murphysboro, IL?
The driving distance from Niles, IL to Murphysboro, IL is about 348.7 miles (561.1 km), with a travel time of about 06h 38m by car.
- The straight-line flight distance is about 305 miles (490.8 km).
- For a round trip, plan for roughly 13h 17m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 38m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Illinois
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between Niles and Murphysboro.
Turn-by-Turn Driving Directions
Step-by-step road directions between Niles and Murphysboro.
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1
Start on North Waukegan Road
4 m · 5 sec · North Waukegan Road
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2
Turn right onto West Howard Street
3171 ft · 1 min · West Howard Street
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3
Turn right onto North Caldwell Avenue
2.9 mi · 4 min · North Caldwell Avenue
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4
Take the ramp straight toward I 94 East
1370 ft · 35 sec
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5
Merge slight left onto Edens Expressway
2.1 mi · 2 min · Edens Expressway
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6
Continue on Kennedy Expressway
8.1 mi · 12 min · Kennedy Expressway
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7
Continue on Dan Ryan Expressway
2.4 mi · 3 min · Dan Ryan Expressway
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8
Keep slight left to continue on Dan Ryan Expressway (Express)
8.8 mi · 12 min · Dan Ryan Expressway (Express)
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9
Keep slight right to continue on I 57 South: Memphis
200.8 mi · 3 hr 41 min
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10
Keep slight left to continue on I 57 South: Memphis
65.7 mi · 1 hr 11 min
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11
Keep slight right to continue on Ken Gray Expressway
32.7 mi · 35 min · Ken Gray Expressway
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12
Take the exit slight right toward Johnston City, Herrin
1506 ft · 39 sec
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13
Turn right onto Herrin Road
3.1 mi · 5 min · Herrin Road
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14
Continue on East Herrin Street
3.1 mi · 5 min · East Herrin Street
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15
Continue on Herrin Road
3.5 mi · 5 min · Herrin Road
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16
Enter the roundabout and take exit 1 toward Cambria Road
11 m · 1 sec · Cambria Road
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17
Exit the roundabout onto Cambria Road
1.5 mi · 2 min · Cambria Road
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18
Turn left onto Russell Street
11.3 mi · 16 min · Russell Street
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19
Turn left onto North 2nd Street
1.4 km · 1 min · North 2nd Street
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20
Turn right onto Walnut Street
2911 ft · 1 min · Walnut Street
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21
Turn right onto North 11th Street
20 m · 3 sec · North 11th Street
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22
Arrive at your destination
0 m · 1 sec · North 11th Street
Car Route Details
A richer read on the saved driving route between Niles and Murphysboro.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
I 57 South
Keep slight right to continue on I 57 South: Memphis
201 mi · 03h 41m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Rain Showers leaving Niles and Showers And Thunderstorms Likely near Murphysboro.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Niles to Murphysboro?
The road trip is about 348.7 miles (561.1 km) and usually takes 06h 38m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Tuscola is a useful midpoint, sitting about 174.3 miles from Niles and 174.4 miles from Murphysboro.
How much longer is the road route than the straight-line distance?
The direct path is about 305 miles (490.8 km), while the road route adds roughly 43.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $57.38 one way or $114.76 round trip. Estimated CO2 is about 109.3 kg one way.
What should you check before leaving?
Before you leave, expect Rain Showers around Niles and Showers And Thunderstorms Likely near Murphysboro.
Stop Ideas Near Tuscola
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Tuscola.
Illinois Terminal
Mattoon station
Rantoul
Danville, Illinois
Flight Path Map
This map shows the direct air route between Niles and Murphysboro. Straight-line distance: 304.95 mi (490.77 km).
#1 Niles
City in Trumbull County, Ohio
| Population | 28,615 |
| Coordinates | 42.0189200, -87.8028400 |
| Altitude | 194 |
| Country | United States |
#2 Murphysboro
Town in Illinois
| Population | 7,384 |
| Coordinates | 37.7645000, -89.3350900 |
| Altitude | 128 |
| Country | United States |
End: Murphysboro (-89.33509, 37.7645)
Estimated Travel Time
Distance: 561 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 37m |
| 40 mph (64.37 km/h) | 08h 43m |
| 50 mph (80.47 km/h) | 06h 58m |
| 60 mph (96.56 km/h) | 05h 48m |
| 70 mph (112.65 km/h) | 04h 58m |
| 80 mph (129 km/h) | 04h 20m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.67 | $57.38 | $114.76 |
| Mid-grade | $5.29 | $65.09 | $130.18 |
| Premium | $5.84 | $71.80 | $143.59 |
| Diesel | $6.57 | $80.82 | $161.65 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Illinois · Oct 15, 2026