How far is Moorhead, MS from Biloxi, MS?
Fastest route
The distance between Moorhead, Mississippi 38761, and Biloxi, Mississippi is approximately 259 miles (417 kilometers). The estimated travel time is 4 hours and 10 minutes. The fastest route at the moment is via US 49 S.
Directions
- Head south on Hwy 3 S/Olive St toward N Southern Ave.
- Continue to follow Hwy 3 S.
- Continue on US-49W S.
- Take US 49 S and MS-67 S to Division St in Biloxi.
- Take exit 1C from I-110.
- Keep right at the fork, follow signs for US-49 S/Jackson and merge onto US 49 S/Jerry Clower Blvd.
- Continue to follow US 49 S.
- Use the right lane to take the ramp onto I-220 S/US 49 S.
- Keep left to continue on US 49 S, follow signs for I-20 E/Meridian/Hattiesburg.
- Merge onto I-20 E/US 49 S.
- Use the right 2 lanes to keep right at the fork, continue on I-20 E/US 49 S, and follow signs for Hattiesburg/Meridian.
- Use the right 2 lanes to take exit 47A to merge onto US 49 S toward Hattiesburg.
- Take exit 59 for US-98 E toward Lucedale/Mobile.
- Continue onto US-98 E/US-98 BYP E.
- Use the right lane to take the ramp to Gulfport.
- Keep right to stay on US 49 S.
- Continue straight to stay on US 49 S.
- Use the right lane to take the MS-67 S ramp to D'Iberville/Biloxi.
- Continue onto I-110/MS-15 S.
- Take exit 1C for Division St.
- Take Caillavet St and Esters Blvd to Howard Ave.
- Use the left 2 lanes to turn left onto Division St.
- Turn right at the 3rd cross street onto Caillavet St.
- Turn left onto Esters Blvd.
- Turn left onto Howard Ave.
Tips & Suggestions
- 🚗 Consider taking regular breaks during the journey to avoid fatigue.
- 🛣️ Stay updated on traffic conditions to choose the fastest route.
- ⛽ Ensure your vehicle has enough fuel for the journey.
- 📱 Use a navigation app or GPS device for real-time guidance.
- 🍴 Pack some snacks and water for the road to keep yourself refreshed.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 21m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Mississippi
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Moorhead and Biloxi.
Turn-by-Turn Driving Directions
Step-by-step road directions between Moorhead and Biloxi.
-
1
Start on Olive Street
7.4 mi · 13 min · Olive Street
-
2
At the end of the road, turn left onto North Martin Luther King Drive
39.7 mi · 47 min · North Martin Luther King Drive
-
3
Keep slight right to continue on US 49 South: Jackson
2791 ft · 53 sec
-
4
Merge slight right onto Jerry Clower Boulevard
38.8 mi · 48 min · Jerry Clower Boulevard
-
5
Take the exit slight right
4.9 mi · 6 min
-
6
Keep slight left
3.8 mi · 5 min
-
7
Merge slight right
1.1 mi · 1 min
-
8
Keep slight right to continue on Meridian, Hattiesburg
106 m · 5 sec
-
9
Take the exit slight right toward Hattiesburg
2977 ft · 42 sec
-
10
Keep slight right to continue on Richland, Hattiesburg
1.2 km · 2 min
-
11
Merge slight left onto Highway 49 South
80.3 mi · 1 hr 37 min · Highway 49 South
-
12
Continue straight
2294 ft · 36 sec
-
13
Continue straight
1.1 mi · 2 min
-
14
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
1914 ft · 36 sec
-
15
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
7.7 mi · 8 min · Lance Corporal Roy M Wheat Memorial Highway
-
16
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi · 4 min
-
17
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
1558 ft · 44 sec
-
18
Keep slight left to continue on Multi Purpose Center, Hattiesburg
833 ft · 26 sec
-
19
Turn right
41.9 mi · 49 min
-
20
Take the exit slight right toward MS 67 South: D'Iberville, Biloxi
1.2 km · 1 min
-
21
Continue on Biloxi-D'Iberville Scenic Expressway
20.5 mi · 24 min · Biloxi-D'Iberville Scenic Expressway
-
22
Continue straight
3.2 mi · 4 min
-
23
Take the exit slight right toward Division Street
1852 ft · 47 sec
-
24
Turn left onto Division Street
3090 ft · 2 min · Division Street
-
25
Turn right onto Main Street
2572 ft · 1 min · Main Street
-
26
Turn left onto Howard Avenue
28 m · 3 sec · Howard Avenue
-
27
Arrive at your destination
0 m · 1 sec · Howard Avenue
Car Route Details
A richer read on the saved driving route between Moorhead and Biloxi.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Highway 49 South
Merge slight left onto Highway 49 South
80.3 mi · 01h 37m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny leaving Moorhead and Mostly Sunny near Biloxi.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Moorhead to Biloxi?
The road trip is about 260.2 miles (418.7 km) and usually takes 04h 21m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Mendenhall is a useful midpoint, sitting about 129.6 miles from Moorhead and 130.6 miles from Biloxi.
How much longer is the road route than the straight-line distance?
The direct path is about 231.4 miles (372.4 km), while the road route adds roughly 28.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:18 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $34.76 one way or $69.53 round trip. Estimated CO2 is about 81.6 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny around Moorhead and Mostly Sunny near Biloxi.
Stop Ideas Near Mendenhall
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Mendenhall.
Union Station
Hazlehurst station
Brookhaven
Laurel station
Flight Path Map
This map shows the direct air route between Moorhead and Biloxi. Straight-line distance: 231.42 mi (372.43 km).
#1 Moorhead
City in Mississippi, United States
| Population | 2,059 |
| Coordinates | 33.4501200, -90.5056400 |
| Altitude | 35 |
| Country | United States |
#2 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
End: Howard Avenue (-88.885301, 30.396075)
Estimated Travel Time
Distance: 419 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 40m |
| 40 mph (64.37 km/h) | 06h 30m |
| 50 mph (80.47 km/h) | 05h 12m |
| 60 mph (96.56 km/h) | 04h 20m |
| 70 mph (112.65 km/h) | 03h 42m |
| 80 mph (129 km/h) | 03h 14m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $34.76 | $69.53 |
| Mid-grade | $4.26 | $39.10 | $78.20 |
| Premium | $4.63 | $42.46 | $84.91 |
| Diesel | $5.42 | $49.71 | $99.42 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · May 05, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.