How far is Mesopotamia, OH from Hamilton, OH?
The driving distance from Mesopotamia, OH to Hamilton, OH is about 276.3 miles (444.6 km), with a travel time of about 04h 30m by car.
- The straight-line flight distance is about 237.1 miles (381.5 km).
- For a round trip, plan for roughly 09h 01m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 30m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Morrow County, Ohio, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny
Sunny
Driving Route Map
The map below follows the saved road route between Mesopotamia and Hamilton.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mesopotamia and Hamilton.
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1
Start on Kinsman Road
5.6 mi · 8 min · Kinsman Road
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2
Continue on East High Street
1.6 mi · 3 min · East High Street
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3
Continue on Kinsman Road
2.4 mi · 4 min · Kinsman Road
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4
Continue on East Center Street
2376 ft · 59 sec · East Center Street
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5
Enter the roundabout and take exit 5 toward the route
1437 ft · 49 sec
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6
Exit the roundabout
2.5 mi · 4 min
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7
Turn left onto Ravenna Road
6.3 mi · 10 min · Ravenna Road
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8
Take the ramp right toward US 422 West: Cleveland
1921 ft · 47 sec
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9
Merge slight left
12.7 mi · 15 min
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10
Take the exit slight right toward Cochran Road, Harper Road
2228 ft · 58 sec
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11
Turn right onto Harper Road
810 ft · 29 sec · Harper Road
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12
Turn left onto Cannon Road
1.5 km · 2 min · Cannon Road
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13
Continue on Cannon Road
1.3 km · 1 min · Cannon Road
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14
Continue on Rockside Road
2569 ft · 58 sec · Rockside Road
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15
Take the ramp left toward I 271 South, I 480 East
1588 ft · 39 sec
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16
Merge slight left onto Outerbelt South Freeway
3010 ft · 43 sec · Outerbelt South Freeway
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17
Merge slight left onto Outerbelt East Freeway
1.1 mi · 1 min · Outerbelt East Freeway
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18
Keep slight left
24.3 mi · 27 min
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19
Merge slight left
113.2 mi · 2 hr 3 min
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20
Keep slight right
81.7 mi · 1 hr 29 min
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21
Take the exit slight right toward SR 741 North: Kings Mills Road, Mason
1504 ft · 41 sec
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22
Turn right onto Kings Mills Road
2 mi · 4 min · Kings Mills Road
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23
Turn sharp left
922 ft · 16 sec
-
24
Continue straight
1.5 mi · 2 min
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25
Turn right onto West Main Street
1390 ft · 29 sec · West Main Street
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26
Turn right onto Mason Road
2220 ft · 44 sec · Mason Road
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27
Enter the roundabout and take exit 3 toward Mason Road
54 m · 4 sec · Mason Road
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28
Exit the roundabout onto Mason Road
1.1 km · 1 min · Mason Road
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29
Enter the roundabout and take exit 1 toward Mason Road
25 m · 2 sec · Mason Road
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30
Exit the roundabout onto Mason Road
1.3 km · 1 min · Mason Road
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31
Continue on Liberty Way
1.3 km · 2 min · Liberty Way
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32
Turn right onto Cox Lane
1581 ft · 32 sec · Cox Lane
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33
Enter the roundabout and take exit 3 toward Veterans Boulevard
92 m · 6 sec · Veterans Boulevard
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34
Exit the roundabout onto Veterans Boulevard
1274 ft · 23 sec · Veterans Boulevard
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35
Continue on Butler County Veterans Highway
9.3 mi · 11 min · Butler County Veterans Highway
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36
Continue on High Street
1.7 mi · 3 min · High Street
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37
Continue on High Street
69 m · 15 sec · High Street
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38
Arrive at your destination
0 m · 1 sec · High Street
Car Route Details
A richer read on the saved driving route between Mesopotamia and Hamilton.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Outerbelt East Freeway
Merge slight left
113 mi · 02h 03m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny leaving Mesopotamia and Sunny near Hamilton.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Mesopotamia to Hamilton?
The road trip is about 276.3 miles (444.6 km) and usually takes 04h 30m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Marengo is a useful midpoint, sitting about 137.2 miles from Mesopotamia and 139.1 miles from Hamilton.
How much longer is the road route than the straight-line distance?
The direct path is about 237.1 miles (381.5 km), while the road route adds roughly 39.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 7:58 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $36.12 one way or $72.25 round trip. Estimated CO2 is about 86.6 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny around Mesopotamia and Sunny near Hamilton.
Stop Ideas Near Marengo
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Marengo.
Columbus, OH
Sandusky
Flight Path Map
This map shows the direct air route between Mesopotamia and Hamilton. Straight-line distance: 237.05 mi (381.5 km).
#1 Mesopotamia
Township in Trumbull County, Ohio
| Population | 3,171 |
| Coordinates | 41.4583900, -80.9550900 |
| Altitude | 261 |
| Country | United States |
#2 Hamilton
The most populous city in Butler County, Ohio.
| Population | 62,148 |
| Coordinates | 39.3995000, -84.5613400 |
| Altitude | 181 |
| Country | United States |
End: High Street (-84.56131, 39.399555)
Estimated Travel Time
Distance: 445 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 12m |
| 40 mph (64.37 km/h) | 06h 54m |
| 50 mph (80.47 km/h) | 05h 31m |
| 60 mph (96.56 km/h) | 04h 36m |
| 70 mph (112.65 km/h) | 03h 56m |
| 80 mph (129 km/h) | 03h 26m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.71 | $36.12 | $72.25 |
| Mid-grade | $4.24 | $41.36 | $82.72 |
| Premium | $4.79 | $46.70 | $93.41 |
| Diesel | $4.30 | $41.96 | $83.93 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Ohio · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.