How far is Laredo, TX from Santa Fe, TX?
The driving distance from Laredo, TX to Santa Fe, TX is about 329.2 miles (529.8 km), with a travel time of about 06h 35m by car.
- The straight-line flight distance is about 297 miles (478 km).
- For a round trip, plan for roughly 13h 11m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 06h 35m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Texas, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Chance Showers And Thunderstorms then Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Laredo and Santa Fe.
Turn-by-Turn Driving Directions
Step-by-step road directions between Laredo and Santa Fe.
-
1
Start on Matamoros Street
1544 ft · 46 sec · Matamoros Street
-
2
Turn left onto San Dario Avenue
553 ft · 11 sec · San Dario Avenue
-
3
Continue on San Dario Avenue
1 km · 1 min · San Dario Avenue
-
4
Turn right onto Park Street
1727 ft · 35 sec · Park Street
-
5
Continue on Clark Boulevard
3 mi · 6 min · Clark Boulevard
-
6
Turn left onto Bob Bullock Loop
1.3 km · 1 min · Bob Bullock Loop
-
7
Take the ramp slight right
71 m · 6 sec
-
8
Merge slight left onto East Saunders Street
1.1 mi · 2 min · East Saunders Street
-
9
Continue on Lloyd Bentsen Highway
57.6 mi · 1 hr 1 min · Lloyd Bentsen Highway
-
10
Turn left
66.6 mi · 1 hr 18 min
-
11
Continue on West Houston Street
1.6 mi · 4 min · West Houston Street
-
12
Continue on US Highway 59 East
47.7 mi · 53 min · US Highway 59 East
-
13
Take the exit left toward Northwest Zac Lentz Parkway
2904 ft · 1 min · Northwest Zac Lentz Parkway
-
14
Merge slight left
93.2 mi · 1 hr 44 min
-
15
Take the exit slight right
1551 ft · 38 sec
-
16
Continue on 59 Northbound Frontage Road
1.6 mi · 2 min · 59 Northbound Frontage Road
-
17
Continue straight
2146 ft · 59 sec
-
18
Continue on US 59 Northbound Frontage Road
2 mi · 5 min · US 59 Northbound Frontage Road
-
19
Continue on Southwest Freeway Frontage Road
1.3 mi · 3 min · Southwest Freeway Frontage Road
-
20
Take the ramp slight left toward I 69 North, US 59 North
1304 ft · 32 sec
-
21
Merge slight left onto Southwest Freeway
13.9 mi · 15 min · Southwest Freeway
-
22
Take the exit slight right
1047 ft · 18 sec
-
23
Turn straight onto Southwest Freeway Frontage Road
1 km · 59 sec · Southwest Freeway Frontage Road
-
24
Turn right onto State Highway 6 South
6.8 mi · 11 min · State Highway 6 South
-
25
Continue straight
1997 ft · 38 sec
-
26
Continue straight
1.1 mi · 2 min
-
27
Continue straight
1.8 mi · 3 min
-
28
Continue straight
1.3 mi · 2 min
-
29
Continue straight
23.6 mi · 35 min
-
30
Arrive at your destination
0 m · 1 sec · Highway 6
Car Route Details
A richer read on the saved driving route between Laredo and Santa Fe.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Northwest Zac Lentz Parkway
Merge slight left
93.2 mi · 01h 44m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Chance Showers And Thunderstorms leaving Laredo and Chance Showers And Thunderstorms then Showers And Thunderstorms near Santa Fe.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Laredo to Santa Fe?
The road trip is about 329.2 miles (529.8 km) and usually takes 06h 35m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Goliad is a useful midpoint, sitting about 164.5 miles from Laredo and 164.7 miles from Santa Fe.
How much longer is the road route than the straight-line distance?
The direct path is about 297 miles (478 km), while the road route adds roughly 32.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $43.91 one way or $87.82 round trip. Estimated CO2 is about 103.3 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Laredo and Chance Showers And Thunderstorms then Showers And Thunderstorms near Santa Fe.
Flight Path Map
This map shows the direct air route between Laredo and Santa Fe. Straight-line distance: 297.02 mi (478 km).
#1 Laredo
The third most populous city in Texas and the center of the Laredo metropolitan area.
| Population | 263,640 |
| Coordinates | 27.5064100, -99.5075400 |
| Altitude | 126 |
| Country | United States |
#2 Santa Fe
City in Galveston County, Texas, United States
| Population | 13,461 |
| Coordinates | 29.3780100, -95.1057600 |
| Altitude | 9 |
| Country | United States |
End: Santa Fe (-95.10576, 29.37801)
Estimated Travel Time
Distance: 530 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 58m |
| 40 mph (64.37 km/h) | 08h 13m |
| 50 mph (80.47 km/h) | 06h 35m |
| 60 mph (96.56 km/h) | 05h 29m |
| 70 mph (112.65 km/h) | 04h 42m |
| 80 mph (129 km/h) | 04h 06m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.78 | $43.91 | $87.82 |
| Mid-grade | $4.25 | $49.41 | $98.82 |
| Premium | $4.59 | $53.35 | $106.69 |
| Diesel | $3.99 | $46.40 | $92.80 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Texas · May 24, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.