How far is Jefferson City, MO from Caruthersville, MO?
The driving distance from Jefferson City, MO to Caruthersville, MO is about 291.1 miles (468.5 km), with a travel time of about 05h 46m by car.
- The straight-line flight distance is about 215 miles (346 km).
- For a round trip, plan for roughly 11h 33m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 46m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Sainte Genevieve County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Slight Chance Rain Showers then Sunny
Driving Route Map
The map below follows the saved road route between Jefferson City and Caruthersville.
Turn-by-Turn Driving Directions
Step-by-step road directions between Jefferson City and Caruthersville.
-
1
Start on East Wall Way
47 m · 13 sec · East Wall Way
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2
Turn right onto Jefferson Street
1130 ft · 40 sec · Jefferson Street
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3
Turn left onto Rex M Whitton Expressway
11.3 mi · 14 min · Rex M Whitton Expressway
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4
Keep slight left to continue on US 50 East: Saint Louis
5.9 mi · 7 min
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5
Turn left onto Wolf Ridge Trail
1995 ft · 2 min · Wolf Ridge Trail
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6
At the end of the road, turn right onto Loose Creek Highway
1 mi · 2 min · Loose Creek Highway
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7
Continue on County Route 604
1 km · 3 min · County Route 604
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8
Turn left onto County Route 605
1.5 mi · 6 min · County Route 605
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9
Turn left
1817 ft · 36 sec
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10
Continue on West Main Street
58.6 mi · 1 hr 10 min · West Main Street
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11
Merge slight left
2.5 mi · 3 min
-
12
Keep slight left to continue on I 44 East, US 50 East: Saint Louis
17.3 mi · 19 min
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13
Take the exit slight right toward MO 109: Eureka, Wildwood
1115 ft · 27 sec
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14
Turn right
2.1 mi · 4 min
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15
Turn left
6.4 mi · 11 min
-
16
Continue straight
11.6 mi · 17 min
-
17
Take the exit slight right
55 m · 5 sec
-
18
Turn right onto Metropolitan Boulevard
641 ft · 15 sec · Metropolitan Boulevard
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19
Enter the roundabout and take exit 3 toward I 55 South: Cape Girardeau
66 m · 10 sec
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20
Exit the roundabout onto I 55 South: Cape Girardeau
832 ft · 10 sec
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21
Merge slight left onto Jeff McBride Memorial Highway
165.6 mi · 2 hr 57 min · Jeff McBride Memorial Highway
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22
Take the exit slight right toward MO 84: Hayti, Caruthersville
1096 ft · 31 sec
-
23
Turn left
5.1 mi · 9 min
-
24
Turn right
14 m · 3 sec
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25
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Jefferson City and Caruthersville.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Jeff McBride Memorial Highway
Merge slight left onto Jeff McBride Memorial Highway
166 mi · 02h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Sunny leaving Jefferson City and Slight Chance Rain Showers then Sunny near Caruthersville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Jefferson City to Caruthersville?
The road trip is about 291.1 miles (468.5 km) and usually takes 05h 46m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Bloomsdale is a useful midpoint, sitting about 145.6 miles from Jefferson City and 145.6 miles from Caruthersville.
How much longer is the road route than the straight-line distance?
The direct path is about 215 miles (346 km), while the road route adds roughly 76.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:26 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $38.73 one way or $77.46 round trip. Estimated CO2 is about 91.3 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Jefferson City and Slight Chance Rain Showers then Sunny near Caruthersville.
Stop Ideas Near Bloomsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Bloomsdale.
Kirkwood
Gateway Transportation Center
Du Quoin
Carbondale station
Flight Path Map
This map shows the direct air route between Jefferson City and Caruthersville. Straight-line distance: 214.99 mi (346 km).
#1 Jefferson City
The capital of Missouri.
| Population | 42,708 |
| Coordinates | 38.5767000, -92.1735200 |
| Altitude | 192 |
| Country | United States |
#2 Caruthersville
City in and county seat of Pemiscot County, Missouri, United States
| Population | 5,289 |
| Coordinates | 36.1931200, -89.6556400 |
| Altitude | 84 |
| Country | United States |
End: Caruthersville (-89.65564, 36.19312)
Estimated Travel Time
Distance: 469 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 42m |
| 40 mph (64.37 km/h) | 07h 16m |
| 50 mph (80.47 km/h) | 05h 49m |
| 60 mph (96.56 km/h) | 04h 51m |
| 70 mph (112.65 km/h) | 04h 09m |
| 80 mph (129 km/h) | 03h 37m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $38.73 | $77.46 |
| Mid-grade | $4.25 | $43.68 | $87.36 |
| Premium | $4.65 | $47.80 | $95.59 |
| Diesel | $5.30 | $54.47 | $108.94 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.