How far is Independence, MO from Sainte Genevieve, MO?
The driving distance from Independence, MO to Sainte Genevieve, MO is about 289.7 miles (466.2 km), with a travel time of about 05h 36m by car.
- The straight-line flight distance is about 248.5 miles (399.9 km).
- For a round trip, plan for roughly 11h 13m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 36m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Callaway County, Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Independence and Sainte Genevieve.
Turn-by-Turn Driving Directions
Step-by-step road directions between Independence and Sainte Genevieve.
-
1
Start on East Kansas Avenue
44 m · 8 sec · East Kansas Avenue
-
2
Turn right onto South Lynn Street
120 m · 23 sec · South Lynn Street
-
3
Turn left onto East Walnut Street
142 m · 25 sec · East Walnut Street
-
4
Turn right onto South Noland Road
3.1 mi · 5 min · South Noland Road
-
5
Turn left onto I 70 East: Columbia, Saint Louis
1089 ft · 27 sec
-
6
Merge slight left onto Clifton J. Scott Memorial Highway
1.5 mi · 2 min · Clifton J. Scott Memorial Highway
-
7
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
-
8
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
-
9
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
-
10
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
-
11
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
-
12
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
-
13
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
-
14
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
-
15
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
-
16
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
-
17
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
-
18
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
-
19
Merge slight left
11.5 mi · 14 min
-
20
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
-
21
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
-
22
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
-
23
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
-
24
Continue on Police Officer Steven Jarvis Memorial Highway
38.1 mi · 41 min · Police Officer Steven Jarvis Memorial Highway
-
25
Take the exit slight right toward MO O
1139 ft · 31 sec
-
26
Turn left
1329 ft · 38 sec
-
27
Turn right
7.3 mi · 11 min
-
28
Turn left onto Market Street
1.2 mi · 3 min · Market Street
-
29
Turn left onto South Main Street
823 ft · 25 sec · South Main Street
-
30
Turn right onto Jefferson Street
133 m · 19 sec · Jefferson Street
-
31
Arrive at your destination
0 m · 1 sec · Jefferson Street
Car Route Details
A richer read on the saved driving route between Independence and Sainte Genevieve.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
81 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely leaving Independence and Showers And Thunderstorms near Sainte Genevieve.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Independence to Sainte Genevieve?
The road trip is about 289.7 miles (466.2 km) and usually takes 05h 36m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Kingdom City is a useful midpoint, sitting about 144.6 miles from Independence and 145 miles from Sainte Genevieve.
How much longer is the road route than the straight-line distance?
The direct path is about 248.5 miles (399.9 km), while the road route adds roughly 41.2 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 5:46 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $38.54 one way or $77.08 round trip. Estimated CO2 is about 90.8 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely around Independence and Showers And Thunderstorms near Sainte Genevieve.
Stop Ideas Near Kingdom City
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Kingdom City.
Jefferson City
Hermann
Washington
Sedalia
Flight Path Map
This map shows the direct air route between Independence and Sainte Genevieve. Straight-line distance: 248.47 mi (399.88 km).
#1 Independence
A city in Jackson County, Missouri.
| Population | 116,774 |
| Coordinates | 39.0911200, -94.4155100 |
| Altitude | 315 |
| Country | United States |
#2 Sainte Genevieve
City in and the county seat of Ste.
| Population | 4,410 |
| Coordinates | 37.9814400, -90.0417800 |
| Altitude | 117 |
| Country | United States |
End: Sainte Genevieve (-90.04178, 37.98144)
Estimated Travel Time
Distance: 466 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 39m |
| 40 mph (64.37 km/h) | 07h 14m |
| 50 mph (80.47 km/h) | 05h 47m |
| 60 mph (96.56 km/h) | 04h 49m |
| 70 mph (112.65 km/h) | 04h 08m |
| 80 mph (129 km/h) | 03h 36m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $38.54 | $77.08 |
| Mid-grade | $4.25 | $43.47 | $86.93 |
| Premium | $4.65 | $47.56 | $95.13 |
| Diesel | $5.30 | $54.21 | $108.41 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 18, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.