How far is Independence, MO from East Prairie, MO?
The driving distance from Independence, MO to East Prairie, MO is about 390 miles (627.7 km), with a travel time of about 07h 21m by car.
- The straight-line flight distance is about 317.1 miles (510.4 km).
- For a round trip, plan for roughly 14h 43m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 21m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Saint Charles County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Driving Route Map
The map below follows the saved road route between Independence and East Prairie.
Turn-by-Turn Driving Directions
Step-by-step road directions between Independence and East Prairie.
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1
Start on East Kansas Avenue
44 m · 8 sec · East Kansas Avenue
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2
Turn right onto South Lynn Street
120 m · 23 sec · South Lynn Street
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3
Turn left onto East Walnut Street
142 m · 25 sec · East Walnut Street
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4
Turn right onto South Noland Road
3.1 mi · 5 min · South Noland Road
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5
Turn left onto I 70 East: Columbia, Saint Louis
1089 ft · 27 sec
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6
Merge slight left onto Clifton J. Scott Memorial Highway
1.5 mi · 2 min · Clifton J. Scott Memorial Highway
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7
Continue on Truman/Eisenhower Presidential Highway
2.6 mi · 3 min · Truman/Eisenhower Presidential Highway
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8
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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9
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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10
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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11
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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12
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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13
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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14
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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15
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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16
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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17
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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18
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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19
Merge slight left
11.5 mi · 14 min
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20
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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21
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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22
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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23
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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24
Continue on Police Officer Steven Jarvis Memorial Highway
127.1 mi · 2 hr 16 min · Police Officer Steven Jarvis Memorial Highway
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25
Take the exit slight right toward I 57 North, US 60 East: Chicago
1264 ft · 31 sec
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26
Merge slight left
10.3 mi · 11 min
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27
Take the exit slight right toward I 57 Business North, MO 105: Charleston, East Prairie
1111 ft · 27 sec
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28
Turn right onto South Main Street
9.4 mi · 13 min · South Main Street
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29
Turn left onto North Washington Street
1650 ft · 38 sec · North Washington Street
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30
Turn left onto East Main Street
26 m · 4 sec · East Main Street
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31
Arrive at your destination
0 m · 1 sec · East Main Street
Car Route Details
A richer read on the saved driving route between Independence and East Prairie.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
127 mi · 02h 16m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving Independence and Sunny near East Prairie.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Independence to East Prairie?
The road trip is about 390 miles (627.7 km) and usually takes 07h 21m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Foristell is a useful midpoint, sitting about 194.9 miles from Independence and 195.2 miles from East Prairie.
How much longer is the road route than the straight-line distance?
The direct path is about 317.1 miles (510.4 km), while the road route adds roughly 72.9 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $51.89 one way or $103.78 round trip. Estimated CO2 is about 122.3 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around Independence and Sunny near East Prairie.
Stop Ideas Near Foristell
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Park
Warrenton City Animal Control
City of O'Fallon
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Foristell.
Washington
Hermann
Kirkwood
Gateway Transportation Center
Flight Path Map
This map shows the direct air route between Independence and East Prairie. Straight-line distance: 317.15 mi (510.41 km).
#1 Independence
A city in Jackson County, Missouri.
| Population | 116,774 |
| Coordinates | 39.0911200, -94.4155100 |
| Altitude | 315 |
| Country | United States |
#2 East Prairie
City in Mississippi County, Missouri, United States
| Population | 2,924 |
| Coordinates | 36.7797800, -89.3856300 |
| Altitude | 93 |
| Country | United States |
End: East Prairie (-89.38563, 36.77978)
Estimated Travel Time
Distance: 628 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 59m |
| 40 mph (64.37 km/h) | 09h 45m |
| 50 mph (80.47 km/h) | 07h 48m |
| 60 mph (96.56 km/h) | 06h 30m |
| 70 mph (112.65 km/h) | 05h 34m |
| 80 mph (129 km/h) | 04h 51m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $51.89 | $103.78 |
| Mid-grade | $4.25 | $58.52 | $117.04 |
| Premium | $4.65 | $64.04 | $128.08 |
| Diesel | $5.30 | $72.98 | $145.97 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.