How far is Humansville, MO from O'Fallon, MO?
The driving distance from Humansville, MO to O'Fallon, MO is about 215.2 miles (346.4 km), with a travel time of about 03h 30m by car.
- The straight-line flight distance is about 171.1 miles (275.4 km).
- For a round trip, plan for roughly 07h 00m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 30m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Unincorporated community in Missouri
Route Weather Snapshot
Check the forecast at both ends before you head out.
Mostly Sunny then Slight Chance Showers And Thunderstorms
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Humansville and O'Fallon.
Turn-by-Turn Driving Directions
Step-by-step road directions between Humansville and O'Fallon.
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1
Start on West Tilden Street
145 m · 18 sec · West Tilden Street
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2
At the end of the road, turn left onto South Bolivar Road
134 m · 14 sec · South Bolivar Road
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3
Turn right onto East Buffalo Street
1892 ft · 43 sec · East Buffalo Street
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4
Turn left onto North Cypress Street
7.2 mi · 13 min · North Cypress Street
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5
Turn right
80.9 mi · 1 hr 42 min
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6
Turn straight
56.1 mi · 1 hr 3 min
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7
Take the exit slight right toward I 70 East, US 40 East: Saint Louis
1220 ft · 15 sec
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8
Merge slight left onto Dwight D. Eisenhower Highway
69.2 mi · 1 hr 20 min · Dwight D. Eisenhower Highway
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9
Take the exit slight right toward MO K: O'Fallon
1765 ft · 43 sec
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10
Turn straight onto Drennen Parkway
46 m · 3 sec · Drennen Parkway
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11
Keep slight right to continue on Drennen Parkway
51 m · 6 sec · Drennen Parkway
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12
Turn slight left onto MO K: O'Fallon
19 m · 3 sec
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13
Continue on South Main Street
3115 ft · 2 min · South Main Street
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14
Turn right
8 m · 2 sec
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15
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between Humansville and O'Fallon.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
Longest stretch
Turn right
80.9 mi · 01h 42m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Mostly Sunny then Slight Chance Showers And Thunderstorms leaving Humansville and Mostly Sunny near O'Fallon.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Humansville to O'Fallon?
The road trip is about 215.2 miles (346.4 km) and usually takes 03h 30m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Honey Creek is a useful midpoint, sitting about 107.5 miles from Humansville and 107.7 miles from O'Fallon.
How much longer is the road route than the straight-line distance?
The direct path is about 171.1 miles (275.4 km), while the road route adds roughly 44.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 10:00 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $28.62 one way or $57.24 round trip. Estimated CO2 is about 67.5 kg one way.
What should you check before leaving?
Before you leave, expect Mostly Sunny then Slight Chance Showers And Thunderstorms around Humansville and Mostly Sunny near O'Fallon.
Stop Ideas Near Honey Creek
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Honey Creek.
Jefferson City
Hermann
Sedalia
Washington
Flight Path Map
This map shows the direct air route between Humansville and O'Fallon. Straight-line distance: 171.11 mi (275.37 km).
#1 Humansville
City in Polk County, Missouri, United States
| Population | 1,070 |
| Coordinates | 37.7944800, -93.5779800 |
| Altitude | 294 |
| Country | United States |
#2 O'Fallon
The most populous city in St.
| Population | 89,769 |
| Coordinates | 38.8106100, -90.6998500 |
| Altitude | 165 |
| Country | United States |
End: (-90.699849, 38.810674)
Estimated Travel Time
Distance: 346 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 10m |
| 40 mph (64.37 km/h) | 05h 22m |
| 50 mph (80.47 km/h) | 04h 18m |
| 60 mph (96.56 km/h) | 03h 35m |
| 70 mph (112.65 km/h) | 03h 04m |
| 80 mph (129 km/h) | 02h 41m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $28.62 | $57.24 |
| Mid-grade | $4.25 | $32.28 | $64.56 |
| Premium | $4.65 | $35.32 | $70.65 |
| Diesel | $5.30 | $40.26 | $80.51 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 04, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.