How far is Hillsboro, MO from Saint Joseph, MO?
The driving distance from Hillsboro, MO to Saint Joseph, MO is about 322.6 miles (519.2 km), with a travel time of about 05h 08m by car.
- The straight-line flight distance is about 253.3 miles (407.6 km).
- For a round trip, plan for roughly 10h 17m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 08m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Cooper County, Missouri, USA
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Hillsboro and Saint Joseph.
Turn-by-Turn Driving Directions
Step-by-step road directions between Hillsboro and Saint Joseph.
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1
Start on Old State Highway 21
1.3 mi · 3 min · Old State Highway 21
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2
Turn left
53 m · 3 sec
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3
Take the ramp slight right toward MO 21 North: Saint Louis
1797 ft · 24 sec
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4
Merge slight left onto Veterans Memorial Highway
17.1 mi · 20 min · Veterans Memorial Highway
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5
Take the exit slight right toward MO 141: Arnold, Fenton
1384 ft · 24 sec
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6
Turn left
4 mi · 6 min
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7
Keep slight left to continue on MO 141
11.3 mi · 18 min · MO 141
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8
Take the exit slight left toward I 64 West, US 40 West, US 61 North: Wentzville
41 m · 7 sec
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9
Turn left onto I 64 West, US 40 West, US 61 North: Wentzville
1812 ft · 44 sec
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10
Merge slight left onto Avenue of the Saints
22.1 mi · 27 min · Avenue of the Saints
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11
Take the exit slight left toward I 70 West, US 40 West: Kansas City
3047 ft · 1 min
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12
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 1 hr 35 min · Dwight D Eisenhower Highway
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13
Continue on Sheriff Roger I. Wilson Memorial Highway
2 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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14
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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15
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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16
Continue on U.S. Submarine Veterans' Memorial Highway
54.4 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
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17
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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18
Continue on Truman/Eisenhower Presidential Highway
2.7 mi · 3 min · Truman/Eisenhower Presidential Highway
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19
Continue on Clifton J. Scott Memorial Highway
1.8 mi · 2 min · Clifton J. Scott Memorial Highway
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20
Continue on Truman/Eisenhower Presidential Highway
2.9 mi · 3 min · Truman/Eisenhower Presidential Highway
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21
Continue on George Brett Super Highway
1.4 km · 58 sec · George Brett Super Highway
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22
Take the exit slight right toward I 435 North, US 24 East: Des Moines
1.1 mi · 2 min
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23
Merge slight left onto Lamar Hunt Memorial Highway
7.8 mi · 9 min · Lamar Hunt Memorial Highway
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24
Continue on I435 N
1.3 mi · 1 min · I435 N
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25
Continue straight
20.9 mi · 22 min
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26
Keep slight left to continue on I 29 North, US 71 North: Saint Joseph
26 mi · 28 min
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27
Take the exit slight right toward I 229 North: Downtown Saint Joseph
2673 ft · 54 sec
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28
Continue straight
5.7 mi · 7 min
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29
Take the exit slight right toward Central Business District
1382 ft · 34 sec
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30
Continue on Edmond Street
2408 ft · 58 sec · Edmond Street
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31
Turn left onto South 10th Street
841 ft · 21 sec · South 10th Street
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32
Turn right onto Frederick Avenue
116 m · 6 sec · Frederick Avenue
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33
Turn slight right onto Walter Welsh Avenue
42 m · 3 sec · Walter Welsh Avenue
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34
Arrive at your destination
0 m · 1 sec · Walter Welsh Avenue
Car Route Details
A richer read on the saved driving route between Hillsboro and Saint Joseph.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Dwight D Eisenhower Highway
Merge slight left onto Dwight D Eisenhower Highway
80.7 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Hillsboro and Chance Showers And Thunderstorms near Saint Joseph.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Hillsboro to Saint Joseph?
The road trip is about 322.6 miles (519.2 km) and usually takes 05h 08m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Boonville is a useful midpoint, sitting about 161.1 miles from Hillsboro and 161.5 miles from Saint Joseph.
How much longer is the road route than the straight-line distance?
The direct path is about 253.3 miles (407.6 km), while the road route adds roughly 69.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:42 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $42.91 one way or $85.83 round trip. Estimated CO2 is about 101.1 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Hillsboro and Chance Showers And Thunderstorms near Saint Joseph.
Stop Ideas Near Boonville
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Boonville.
Sedalia
Jefferson City
Warrensburg
Hermann
Flight Path Map
This map shows the direct air route between Hillsboro and Saint Joseph. Straight-line distance: 253.29 mi (407.63 km).
#1 Hillsboro
City in Missouri, United States
| Population | 3,355 |
| Coordinates | 38.2322800, -90.5629000 |
| Altitude | 242 |
| Country | United States |
#2 Saint Joseph
The most populous city in Buchanan County, Missouri.
| Population | 74,074 |
| Coordinates | 39.7686100, -94.8466300 |
| Altitude | 270 |
| Country | United States |
End: Walter Welsh Avenue (-94.846632, 39.768853)
Estimated Travel Time
Distance: 519 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 10h 44m |
| 40 mph (64.37 km/h) | 08h 03m |
| 50 mph (80.47 km/h) | 06h 27m |
| 60 mph (96.56 km/h) | 05h 22m |
| 70 mph (112.65 km/h) | 04h 36m |
| 80 mph (129 km/h) | 04h 01m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $42.91 | $85.83 |
| Mid-grade | $4.25 | $48.40 | $96.80 |
| Premium | $4.65 | $52.96 | $105.93 |
| Diesel | $5.30 | $60.36 | $120.72 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 31, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.