How far is Guilford, NY from Buffalo, NY?
The driving distance from Guilford, NY to Buffalo, NY is about 221.1 miles (355.8 km), with a travel time of about 03h 53m by car.
- The straight-line flight distance is about 175.4 miles (282.3 km).
- For a round trip, plan for roughly 07h 46m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 03h 53m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Seneca County, New York, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Partly Sunny then Chance Rain Showers
Showers And Thunderstorms Likely
Driving Route Map
The map below follows the saved road route between Guilford and Buffalo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Guilford and Buffalo.
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1
Start on County Route 35
7 mi · 10 min · County Route 35
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2
Continue straight
2785 ft · 47 sec
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3
Turn right onto North Canal Street
1162 ft · 15 sec · North Canal Street
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4
Continue on State Highway 12
6.2 mi · 7 min · State Highway 12
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5
Continue on South Broad Street
1.7 mi · 3 min · South Broad Street
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6
Continue on State Highway 12
1.2 mi · 2 min · State Highway 12
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7
Turn left onto County Road 44
2.8 mi · 4 min · County Road 44
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8
At the end of the road, turn right
1.2 mi · 2 min
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9
Turn right onto County Road 16
11.8 mi · 17 min · County Road 16
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10
At the end of the road, turn right onto State Highway 26
2.2 mi · 3 min · State Highway 26
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11
Continue on State Route 80
2.7 mi · 4 min · State Route 80
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12
Continue on State Route 80
6.1 mi · 9 min · State Route 80
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13
Continue on State Route 13
1.9 mi · 3 min · State Route 13
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14
Continue on McKinley Street
1.1 mi · 2 min · McKinley Street
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15
Continue on Main Street
2491 ft · 1 min · Main Street
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16
Continue on Fabius Road
2 mi · 3 min · Fabius Road
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17
Continue on State Route 80
4.1 mi · 6 min · State Route 80
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18
Continue on Main Street
1.1 km · 2 min · Main Street
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19
Continue on State Route 80
4.4 mi · 7 min · State Route 80
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20
Turn right onto Apulia Road
4.3 mi · 6 min · Apulia Road
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21
Turn slight left onto Cherry Valley Turnpike
18 mi · 23 min · Cherry Valley Turnpike
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22
Continue on East Genesee Street
7.5 mi · 14 min · East Genesee Street
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23
Turn right onto North Fulton Street
815 ft · 13 sec · North Fulton Street
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24
Turn left onto Arterial West
1931 ft · 1 min · Arterial West
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25
Continue on Chase Street
9.8 mi · 11 min · Chase Street
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26
Continue on Auburn Road
1.9 mi · 2 min · Auburn Road
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27
Turn right
4.1 mi · 7 min
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28
Continue straight
97 m · 10 sec
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29
Turn right onto State Route 414
1557 ft · 29 sec · State Route 414
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30
Continue on Ridge Road
66 m · 11 sec · Ridge Road
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31
Take the ramp left
945 ft · 23 sec
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32
Keep slight left to continue on I 90 West: Buffalo
3202 ft · 1 min
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33
Merge slight left onto New York State Thruway
100.8 mi · 1 hr 57 min · New York State Thruway
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34
Take the exit slight right toward NY 33 West: Buffalo
1901 ft · 46 sec
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35
Merge slight left onto Kensington Expressway
6.4 mi · 9 min · Kensington Expressway
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36
Keep slight left to continue on Oak Street
2170 ft · 40 sec
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37
Continue on Oak Street
131 m · 14 sec · Oak Street
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38
Turn right onto Genesee Street
1172 ft · 39 sec · Genesee Street
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39
Turn right onto East Huron Street
729 ft · 34 sec · East Huron Street
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40
Turn left onto Franklin Street
716 ft · 23 sec · Franklin Street
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41
Turn right onto Genesee Street
123 m · 12 sec · Genesee Street
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42
Enter the roundabout toward Niagara Square
119 m · 12 sec · Niagara Square
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43
Arrive at your destination
0 m · 1 sec · Niagara Square
Car Route Details
A richer read on the saved driving route between Guilford and Buffalo.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
New York State Thruway
Merge slight left onto New York State Thruway
101 mi · 01h 57m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Partly Sunny then Chance Rain Showers leaving Guilford and Showers And Thunderstorms Likely near Buffalo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Guilford to Buffalo?
The road trip is about 221.1 miles (355.8 km) and usually takes 03h 53m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Waterloo is a useful midpoint, sitting about 106.9 miles from Guilford and 114.1 miles from Buffalo.
How much longer is the road route than the straight-line distance?
The direct path is about 175.4 miles (282.3 km), while the road route adds roughly 45.7 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 9:14 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $31.27 one way or $62.54 round trip. Estimated CO2 is about 69.3 kg one way.
What should you check before leaving?
Before you leave, expect Partly Sunny then Chance Rain Showers around Guilford and Showers And Thunderstorms Likely near Buffalo.
Stop Ideas Near Waterloo
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Waterloo.
Empire Expo Center
William F. Walsh Regional Transportation Center
Louise M. Slaughter Rochester Station
Rome station
Flight Path Map
This map shows the direct air route between Guilford and Buffalo. Straight-line distance: 175.41 mi (282.29 km).
#1 Guilford
City in Chenango County, New York, United States of America
| Population | 2,768 |
| Coordinates | 42.4042400, -75.4896300 |
| Altitude | 453 |
| Country | United States |
#2 Buffalo
The second most populous city in New York.
| Population | 254,479 |
| Coordinates | 42.8864500, -78.8783700 |
| Altitude | 183 |
| Country | United States |
End: Niagara Square (-78.878786, 42.886515)
Estimated Travel Time
Distance: 356 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 07h 22m |
| 40 mph (64.37 km/h) | 05h 31m |
| 50 mph (80.47 km/h) | 04h 25m |
| 60 mph (96.56 km/h) | 03h 41m |
| 70 mph (112.65 km/h) | 03h 09m |
| 80 mph (129 km/h) | 02h 45m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.01 | $31.27 | $62.54 |
| Mid-grade | $4.48 | $34.95 | $69.90 |
| Premium | $4.86 | $37.92 | $75.83 |
| Diesel | $4.69 | $36.61 | $73.23 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in New York · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.