How far is Greenwood, MO from Cape Girardeau, MO?
The driving distance from Greenwood, MO to Cape Girardeau, MO is about 355.6 miles (572.3 km), with a travel time of about 05h 20m by car.
- The straight-line flight distance is about 283.3 miles (455.9 km).
- For a round trip, plan for roughly 10h 41m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 20m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms Likely
Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Greenwood and Cape Girardeau.
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenwood and Cape Girardeau.
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1
Start on North Ranson Road
1 mi · 3 min · North Ranson Road
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2
Continue on Southeast Ranson Road
2.4 mi · 4 min · Southeast Ranson Road
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3
Continue on Southeast Todd George Parkway
688 ft · 21 sec · Southeast Todd George Parkway
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4
Turn left onto US 50 West: Raytown, Kansas City
1292 ft · 34 sec
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5
Merge slight left
1.3 km · 1 min
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6
Take the exit slight right toward MO 291 North: Hamblen Road, Independence
1076 ft · 26 sec
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7
Turn slight right
65 m · 5 sec
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8
Turn straight
9.3 mi · 13 min
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9
Take the exit slight right toward I 70 East: Saint Louis
2063 ft · 44 sec
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10
Merge slight left onto Truman/Eisenhower Presidential Highway
1.1 mi · 1 min · Truman/Eisenhower Presidential Highway
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11
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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12
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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13
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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14
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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15
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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16
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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17
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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18
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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19
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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20
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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21
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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22
Merge slight left
11.5 mi · 14 min
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23
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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24
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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25
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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26
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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27
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 1 hr 40 min · Police Officer Steven Jarvis Memorial Highway
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28
Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
814 ft · 17 sec
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29
Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau
1354 ft · 29 sec
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30
Continue on North Kingshighway
3.6 mi · 6 min · North Kingshighway
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31
Turn left onto Broadway Street
2 mi · 4 min · Broadway Street
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32
Arrive at your destination
0 m · 1 sec · Broadway Street
Car Route Details
A richer read on the saved driving route between Greenwood and Cape Girardeau.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
93.1 mi · 01h 40m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Showers And Thunderstorms Likely leaving Greenwood and Showers And Thunderstorms near Cape Girardeau.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Greenwood to Cape Girardeau?
The road trip is about 355.6 miles (572.3 km) and usually takes 05h 20m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
New Florence is a useful midpoint, sitting about 174.7 miles from Greenwood and 180.9 miles from Cape Girardeau.
How much longer is the road route than the straight-line distance?
The direct path is about 283.3 miles (455.9 km), while the road route adds roughly 72.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:18 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $47.33 one way or $94.65 round trip. Estimated CO2 is about 111.5 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms Likely around Greenwood and Showers And Thunderstorms near Cape Girardeau.
Stop Ideas Near New Florence
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to New Florence.
Hermann
Washington
Jefferson City
Kirkwood
Flight Path Map
This map shows the direct air route between Greenwood and Cape Girardeau. Straight-line distance: 283.31 mi (455.94 km).
#1 Greenwood
Town in Jackson County, Florida in the United States
| Population | 5,881 |
| Coordinates | 38.8516800, -94.3438400 |
| Altitude | 290 |
| Country | United States |
#2 Cape Girardeau
The second-largest city in Cape Girardeau County, Missouri.
| Population | 41,588 |
| Coordinates | 37.3058800, -89.5181500 |
| Altitude | 108 |
| Country | United States |
End: Broadway Street (-89.518146, 37.305904)
Estimated Travel Time
Distance: 572 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 11h 50m |
| 40 mph (64.37 km/h) | 08h 53m |
| 50 mph (80.47 km/h) | 07h 06m |
| 60 mph (96.56 km/h) | 05h 55m |
| 70 mph (112.65 km/h) | 05h 04m |
| 80 mph (129 km/h) | 04h 26m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $47.33 | $94.65 |
| Mid-grade | $4.25 | $53.38 | $106.75 |
| Premium | $4.65 | $58.41 | $116.82 |
| Diesel | $5.30 | $66.57 | $133.13 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.