How far is Greenville, MS from Picayune, MS?
The driving distance from Greenville, MS to Picayune, MS is about 268.4 miles (432 km), with a travel time of about 05h 25m by car.
- The straight-line flight distance is about 215.1 miles (346.1 km).
- For a round trip, plan for roughly 10h 50m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 25m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Town in Mississippi, US
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers then Partly Sunny
Chance Rain Showers then Mostly Cloudy
Driving Route Map
The map below follows the saved road route between Greenville and Picayune.
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville and Picayune.
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1
Start on South Broadway Street
3 m · 8 sec · South Broadway Street
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2
Turn left onto Main Street
1.4 km · 2 min · Main Street
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3
Turn left
9.2 mi · 14 min
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4
Turn left
15.8 mi · 19 min
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5
Turn right onto North Martin Luther King Drive
46.2 mi · 56 min · North Martin Luther King Drive
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6
Keep slight right to continue on US 49 South: Jackson
2791 ft · 53 sec
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7
Merge slight right onto Jerry Clower Boulevard
38.8 mi · 48 min · Jerry Clower Boulevard
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8
Take the exit slight right
4.9 mi · 6 min
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9
Keep slight left
3.8 mi · 5 min
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10
Merge slight right
1.1 mi · 1 min
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11
Keep slight right to continue on Meridian, Hattiesburg
106 m · 5 sec
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12
Take the exit slight right toward Hattiesburg
2977 ft · 42 sec
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13
Keep slight right to continue on Richland, Hattiesburg
1.2 km · 2 min
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14
Merge slight left onto Highway 49 South
80.3 mi · 1 hr 37 min · Highway 49 South
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15
Continue straight
2294 ft · 36 sec
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16
Continue straight
1.1 mi · 2 min
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17
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
1914 ft · 36 sec
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18
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
60.7 mi · 1 hr 5 min · Lance Corporal Roy M Wheat Memorial Highway
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19
Take the exit slight right toward MS 43: North Picayune
1355 ft · 33 sec
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20
Turn right onto Highway 43 North
1 mi · 2 min · Highway 43 North
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21
Turn straight
151 m · 22 sec
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22
Turn left
1.5 mi · 2 min
-
23
Turn left onto East Canal Street
638 ft · 18 sec · East Canal Street
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24
Arrive at your destination
0 m · 1 sec · East Canal Street
Car Route Details
A richer read on the saved driving route between Greenville and Picayune.
Interchange-aware route
The drive includes several ramps, exits, or merges, so checking the next few maneuvers before busy interchanges is useful.
Highway 49 South
Merge slight left onto Highway 49 South
80.3 mi · 01h 37m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Rain Showers then Partly Sunny leaving Greenville and Chance Rain Showers then Mostly Cloudy near Picayune.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Greenville to Picayune?
The road trip is about 268.4 miles (432 km) and usually takes 05h 25m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Florence is a useful midpoint, sitting about 134.4 miles from Greenville and 134.1 miles from Picayune.
How much longer is the road route than the straight-line distance?
The direct path is about 215.1 miles (346.1 km), while the road route adds roughly 53.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 6:10 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $35.86 one way or $71.73 round trip. Estimated CO2 is about 84.2 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers then Partly Sunny around Greenville and Chance Rain Showers then Mostly Cloudy near Picayune.
Stop Ideas Near Florence
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Florence.
Union Station
Hazlehurst station
Brookhaven
Vicksburg, MS
Flight Path Map
This map shows the direct air route between Greenville and Picayune. Straight-line distance: 215.06 mi (346.1 km).
#1 Greenville
City in Washington County, Mississippi, United States
| Population | 28,315 |
| Coordinates | 33.4089800, -91.0597800 |
| Altitude | 40 |
| Country | United States |
#2 Picayune
City in Pearl River County, Mississippi, United States
| Population | 10,886 |
| Coordinates | 30.5255600, -89.6778800 |
| Altitude | 22 |
| Country | United States |
End: Picayune (-89.67788, 30.52556)
Estimated Travel Time
Distance: 432 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 56m |
| 40 mph (64.37 km/h) | 06h 42m |
| 50 mph (80.47 km/h) | 05h 22m |
| 60 mph (96.56 km/h) | 04h 28m |
| 70 mph (112.65 km/h) | 03h 50m |
| 80 mph (129 km/h) | 03h 20m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $35.86 | $71.73 |
| Mid-grade | $4.26 | $40.33 | $80.67 |
| Premium | $4.63 | $43.80 | $87.60 |
| Diesel | $5.42 | $51.28 | $102.56 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.