How far is Florence, MS from Biloxi, MS?
The driving distance from Florence, MS to Biloxi, MS is about 154.3 miles (248.3 km), with a travel time of about 02h 32m by car.
- The straight-line flight distance is about 142 miles (228.5 km).
- For a round trip, plan for roughly 05h 05m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 8:00 AM to 10:00 AM CDT.
Reverse, save, or send this route
This route works well as a day trip with time at the destination. Copy the route link, send it to another device, or print a clean version before you head out.
This route works well as a day trip with time at the destination.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 02h 32m.
A morning start gives you useful time at the destination and keeps the return out of the late evening.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census designated place
Route Weather Snapshot
Check the forecast at both ends before you head out.
Showers And Thunderstorms
Showers And Thunderstorms then Chance Showers And Thunderstorms
Driving Route Map
The map below follows the saved road route between Florence and Biloxi.
Turn-by-Turn Driving Directions
Step-by-step road directions between Florence and Biloxi.
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1
Start on MS 469
2044 ft · 41 sec · MS 469
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2
Turn right onto Highway 49 South
72 mi · 1 hr 26 min · Highway 49 South
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3
Continue straight
2294 ft · 36 sec
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4
Continue straight
1.1 mi · 2 min
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5
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
1914 ft · 36 sec
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6
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
7.7 mi · 8 min · Lance Corporal Roy M Wheat Memorial Highway
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7
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi · 4 min
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8
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
1558 ft · 44 sec
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9
Keep slight left to continue on Multi Purpose Center, Hattiesburg
833 ft · 26 sec
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10
Turn right
41.9 mi · 49 min
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11
Take the exit slight right toward MS 67 South: D'Iberville, Biloxi
1.2 km · 1 min
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12
Continue on Biloxi-D'Iberville Scenic Expressway
20.5 mi · 24 min · Biloxi-D'Iberville Scenic Expressway
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13
Continue straight
3.2 mi · 4 min
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14
Take the exit slight right toward Division Street
1852 ft · 47 sec
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15
Turn left onto Division Street
3090 ft · 2 min · Division Street
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16
Turn right onto Main Street
2572 ft · 1 min · Main Street
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17
Turn left onto Howard Avenue
28 m · 3 sec · Howard Avenue
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18
Arrive at your destination
0 m · 1 sec · Howard Avenue
Car Route Details
A richer read on the saved driving route between Florence and Biloxi.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Highway 49 South
Turn right onto Highway 49 South
72 mi · 01h 26m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A comfortable day-trip route
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
Showers And Thunderstorms leaving Florence and Showers And Thunderstorms then Chance Showers And Thunderstorms near Biloxi.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Florence to Biloxi?
The road trip is about 154.3 miles (248.3 km) and usually takes 02h 32m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route works well as a day trip. You can leave in the morning, spend meaningful time at the destination, and still return the same day.
What is the halfway point on this route?
West Hattiesburg is a useful midpoint, sitting about 76.7 miles from Florence and 77.5 miles from Biloxi.
How much longer is the road route than the straight-line distance?
The direct path is about 142 miles (228.5 km), while the road route adds roughly 12.3 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 8:00 AM to 10:00 AM CDT. If you want a more comfortable same-day return, try to leave by 1:24 PM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $20.60 one way or $41.20 round trip. Estimated CO2 is about 48.3 kg one way.
What should you check before leaving?
Before you leave, expect Showers And Thunderstorms around Florence and Showers And Thunderstorms then Chance Showers And Thunderstorms near Biloxi.
Stop Ideas Near West Hattiesburg
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to West Hattiesburg.
Hattiesburg station
Hattiesburg, MS
Laurel station
Picayune
Flight Path Map
This map shows the direct air route between Florence and Biloxi. Straight-line distance: 141.98 mi (228.49 km).
#1 Florence
Town in Mississippi, US
| Population | 4,531 |
| Coordinates | 32.1534800, -90.1312000 |
| Altitude | 95 |
| Country | United States |
#2 Biloxi
The most populous city in Harrison County, Mississippi.
| Population | 46,127 |
| Coordinates | 30.3960300, -88.8853100 |
| Altitude | 6 |
| Country | United States |
End: Howard Avenue (-88.885301, 30.396075)
Estimated Travel Time
Distance: 248 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 05h 08m |
| 40 mph (64.37 km/h) | 03h 51m |
| 50 mph (80.47 km/h) | 03h 05m |
| 60 mph (96.56 km/h) | 02h 34m |
| 70 mph (112.65 km/h) | 02h 12m |
| 80 mph (129 km/h) | 01h 55m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.79 | $20.60 | $41.20 |
| Mid-grade | $4.26 | $23.17 | $46.34 |
| Premium | $4.63 | $25.16 | $50.32 |
| Diesel | $5.42 | $29.46 | $58.92 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Mississippi · May 03, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.