How far is East Independence, MO from Sikeston, MO?
The driving distance from East Independence, MO to Sikeston, MO is about 369.2 miles (594.2 km), with a travel time of about 07h 00m by car.
- The straight-line flight distance is about 301.4 miles (485.1 km).
- For a round trip, plan for roughly 14h 01m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 00m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Warren County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny then Slight Chance Showers And Thunderstorms
Sunny
Driving Route Map
The map below follows the saved road route between East Independence and Sikeston.
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence and Sikeston.
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1
Start on East 9th Street South
24 m · 9 sec · East 9th Street South
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2
Turn left onto Main Road
1341 ft · 1 min · Main Road
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3
Turn left onto East Truman Road
1.1 km · 1 min · East Truman Road
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4
Turn right onto Holke Road
1.4 km · 2 min · Holke Road
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5
Turn straight onto South Jackson Drive
1.2 mi · 2 min · South Jackson Drive
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6
Turn left onto East R.D. Mize Road
1268 ft · 37 sec · East R.D. Mize Road
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7
Turn right onto South Little Blue Parkway
1.7 mi · 3 min · South Little Blue Parkway
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8
Take the ramp left toward Little Blue Parkway, 39th Street, Mall Entrance
1489 ft · 38 sec
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9
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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10
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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11
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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12
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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13
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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14
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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15
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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16
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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17
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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18
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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19
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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20
Merge slight left
11.5 mi · 14 min
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21
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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22
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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23
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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24
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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25
Continue on Police Officer Steven Jarvis Memorial Highway
125.8 mi · 2 hr 15 min · Police Officer Steven Jarvis Memorial Highway
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26
Take the exit slight right toward US 62: Sikeston, Bertrand
1057 ft · 38 sec
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27
At the end of the road, turn left onto East Malone Avenue
3.1 mi · 5 min · East Malone Avenue
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28
Turn slight right
54 m · 14 sec
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29
Turn left
33 m · 5 sec
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30
Arrive at your destination
0 m · 1 sec
Car Route Details
A richer read on the saved driving route between East Independence and Sikeston.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
126 mi · 02h 15m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny then Slight Chance Showers And Thunderstorms leaving East Independence and Sunny near Sikeston.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from East Independence to Sikeston?
The road trip is about 369.2 miles (594.2 km) and usually takes 07h 00m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Truesdale is a useful midpoint, sitting about 184.4 miles from East Independence and 184.8 miles from Sikeston.
How much longer is the road route than the straight-line distance?
The direct path is about 301.4 miles (485.1 km), while the road route adds roughly 67.8 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $49.14 one way or $98.27 round trip. Estimated CO2 is about 115.8 kg one way.
What should you check before leaving?
Before you leave, expect Sunny then Slight Chance Showers And Thunderstorms around East Independence and Sunny near Sikeston.
Stop Ideas Near Truesdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Warrenton City Animal Control
Moscow Mills City Hall
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Truesdale.
Hermann
Washington
Kirkwood
Gateway Transportation Center
Flight Path Map
This map shows the direct air route between East Independence and Sikeston. Straight-line distance: 301.44 mi (485.12 km).
#1 East Independence
A census-designated place in Jackson County, Missouri.
| Population | 110,675 |
| Coordinates | 39.0955600, -94.3552300 |
| Altitude | 256 |
| Country | United States |
#2 Sikeston
City in Scott County, Missouri, United States
| Population | 15,968 |
| Coordinates | 36.8767200, -89.5878600 |
| Altitude | 100 |
| Country | United States |
End: Sikeston (-89.58786, 36.87672)
Estimated Travel Time
Distance: 594 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 12h 18m |
| 40 mph (64.37 km/h) | 09h 13m |
| 50 mph (80.47 km/h) | 07h 23m |
| 60 mph (96.56 km/h) | 06h 09m |
| 70 mph (112.65 km/h) | 05h 16m |
| 80 mph (129 km/h) | 04h 36m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $49.14 | $98.27 |
| Mid-grade | $4.25 | $55.42 | $110.83 |
| Premium | $4.65 | $60.64 | $121.28 |
| Diesel | $5.30 | $69.11 | $138.22 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · May 12, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.