How far is East Independence, MO from Portageville, MO?
The driving distance from East Independence, MO to Portageville, MO is about 401.2 miles (645.7 km), with a travel time of about 07h 33m by car.
- The straight-line flight distance is about 314.1 miles (505.5 km).
- For a round trip, plan for roughly 15h 07m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 7:30 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 07h 33m.
Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
City in Saint Charles County, Missouri, United States
Route Weather Snapshot
Check the forecast at both ends before you head out.
Sunny
Slight Chance Rain Showers then Sunny
Driving Route Map
The map below follows the saved road route between East Independence and Portageville.
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence and Portageville.
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1
Start on East 9th Street South
24 m · 9 sec · East 9th Street South
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2
Turn left onto Main Road
1341 ft · 1 min · Main Road
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3
Turn left onto East Truman Road
1.1 km · 1 min · East Truman Road
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4
Turn right onto Holke Road
1.4 km · 2 min · Holke Road
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5
Turn straight onto South Jackson Drive
1.2 mi · 2 min · South Jackson Drive
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6
Turn left onto East R.D. Mize Road
1268 ft · 37 sec · East R.D. Mize Road
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7
Turn right onto South Little Blue Parkway
1.7 mi · 3 min · South Little Blue Parkway
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8
Take the ramp left toward Little Blue Parkway, 39th Street, Mall Entrance
1489 ft · 38 sec
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9
Continue on Dwight D. Eisenhower Highway
52.5 mi · 57 min · Dwight D. Eisenhower Highway
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10
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
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11
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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12
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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13
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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14
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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15
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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16
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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17
Merge slight left onto Avenue of the Saints
25.1 mi · 31 min · Avenue of the Saints
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18
Take the exit slight right toward I 270: Chicago, Memphis
1829 ft · 39 sec
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19
Keep slight right to continue on I 270 South: Memphis
1691 ft · 31 sec
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20
Merge slight left
11.5 mi · 14 min
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21
Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
1911 ft · 27 sec
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22
Keep slight right to continue on I 55 South: Memphis
2031 ft · 44 sec
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23
Merge slight left onto Rosa Parks Highway
1.5 mi · 2 min · Rosa Parks Highway
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24
Continue on Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
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25
Continue on Police Officer Steven Jarvis Memorial Highway
160.1 mi · 2 hr 52 min · Police Officer Steven Jarvis Memorial Highway
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26
Take the exit slight right toward MO 162: Portageville
1184 ft · 25 sec
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27
Turn right
3079 ft · 52 sec
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28
Continue on East Main Street
843 ft · 23 sec · East Main Street
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29
Arrive at your destination
0 m · 1 sec · Main Street
Car Route Details
A richer read on the saved driving route between East Independence and Portageville.
Long-distance drive
This route is long enough that fuel, rest stops, weather, and timing matter more than any single maneuver.
Police Officer Steven Jarvis Memorial Highway
Continue on Police Officer Steven Jarvis Memorial Highway
160 mi · 02h 52m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
Better with a longer stop
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
Sunny leaving East Independence and Slight Chance Rain Showers then Sunny near Portageville.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from East Independence to Portageville?
The road trip is about 401.2 miles (645.7 km) and usually takes 07h 33m in normal driving conditions.
Is this a same-day trip or an overnight route?
This route is long enough that most travelers will be better off planning an overnight stay or a more deliberate stop window.
What is the halfway point on this route?
Lake Saint Louis is a useful midpoint, sitting about 200.5 miles from East Independence and 200.8 miles from Portageville.
How much longer is the road route than the straight-line distance?
The direct path is about 314.1 miles (505.5 km), while the road route adds roughly 87.1 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 7:30 AM CDT. Starting early still helps, but most travelers will want a longer stop or an overnight stay on a route this long.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $53.40 one way or $106.79 round trip. Estimated CO2 is about 125.8 kg one way.
What should you check before leaving?
Before you leave, expect Sunny around East Independence and Slight Chance Rain Showers then Sunny near Portageville.
Stop Ideas Near Lake Saint Louis
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Park
City of O'Fallon
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Lake Saint Louis.
Washington
Kirkwood
Gateway Transportation Center
Hermann
Flight Path Map
This map shows the direct air route between East Independence and Portageville. Straight-line distance: 314.11 mi (505.51 km).
#1 East Independence
A census-designated place in Jackson County, Missouri.
| Population | 110,675 |
| Coordinates | 39.0955600, -94.3552300 |
| Altitude | 256 |
| Country | United States |
#2 Portageville
City in New Madrid County, Missouri, United States
| Population | 2,869 |
| Coordinates | 36.4253400, -89.6995300 |
| Altitude | 87 |
| Country | United States |
End: Portageville (-89.69953, 36.42534)
Estimated Travel Time
Distance: 646 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 13h 22m |
| 40 mph (64.37 km/h) | 10h 01m |
| 50 mph (80.47 km/h) | 08h 01m |
| 60 mph (96.56 km/h) | 06h 41m |
| 70 mph (112.65 km/h) | 05h 43m |
| 80 mph (129 km/h) | 05h 00m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $53.40 | $106.79 |
| Mid-grade | $4.25 | $60.22 | $120.44 |
| Premium | $4.65 | $65.90 | $131.80 |
| Diesel | $5.30 | $75.10 | $150.21 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 19, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.