How far is Cairo, NY from Buffalo, NY?
The driving distance from Cairo, NY to Buffalo, NY is about 296 miles (476.3 km), with a travel time of about 05h 01m by car.
- The straight-line flight distance is about 251.5 miles (404.7 km).
- For a round trip, plan for roughly 10h 03m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM EDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 05h 01m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
You are leaving earlier than the recommended window, which gives you extra margin for breaks and traffic.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Census-designated place in Onondaga County, New York
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Rain Showers then Partly Sunny
Slight Chance Rain Showers then Mostly Sunny
Driving Route Map
The map below follows the saved road route between Cairo and Buffalo.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cairo and Buffalo.
-
1
Start on Main Street
1396 ft · 40 sec · Main Street
-
2
Keep slight right to continue on Jerome Avenue
1715 ft · 50 sec · Jerome Avenue
-
3
Turn left
72 m · 7 sec
-
4
Turn right onto County Road 85
541 ft · 17 sec · County Road 85
-
5
Turn left onto State Highway 23
2158 ft · 36 sec · State Highway 23
-
6
Keep slight right
28.7 mi · 43 min
-
7
Turn right onto River Street
3253 ft · 55 sec · River Street
-
8
Continue on State Highway 30
3.3 mi · 5 min · State Highway 30
-
9
Continue on Main Street
2.3 mi · 5 min · Main Street
-
10
Continue on State Highway 30
2.5 mi · 4 min · State Highway 30
-
11
Continue on Zicha Road
1.1 mi · 2 min · Zicha Road
-
12
Continue on Junction Road
1.2 km · 1 min · Junction Road
-
13
Keep slight left to continue on Junction Road
3004 ft · 57 sec · Junction Road
-
14
Turn right onto State Highway 30A
1.8 mi · 3 min · State Highway 30A
-
15
Continue straight
13.3 mi · 18 min
-
16
Turn straight onto State Highway 5S
2.2 mi · 3 min · State Highway 5S
-
17
Continue on East Main Street
1236 ft · 29 sec · East Main Street
-
18
Take the ramp right
1152 ft · 28 sec
-
19
Keep slight left to continue on I 90 West
2172 ft · 53 sec
-
20
Merge slight left onto New York State Thruway
227 mi · 4 hr 23 min · New York State Thruway
-
21
Take the exit slight right toward NY 33 West: Buffalo
1901 ft · 46 sec
-
22
Merge slight left onto Kensington Expressway
6.4 mi · 9 min · Kensington Expressway
-
23
Keep slight left to continue on Oak Street
2170 ft · 40 sec
-
24
Continue on Oak Street
131 m · 14 sec · Oak Street
-
25
Turn right onto Genesee Street
1172 ft · 39 sec · Genesee Street
-
26
Turn right onto East Huron Street
729 ft · 34 sec · East Huron Street
-
27
Turn left onto Franklin Street
716 ft · 23 sec · Franklin Street
-
28
Turn right onto Genesee Street
123 m · 12 sec · Genesee Street
-
29
Enter the roundabout toward Niagara Square
119 m · 12 sec · Niagara Square
-
30
Arrive at your destination
0 m · 1 sec · Niagara Square
Car Route Details
A richer read on the saved driving route between Cairo and Buffalo.
Straightforward drive
The saved road route has a manageable number of maneuvers and should be easy to follow with normal attention to signs.
New York State Thruway
Merge slight left onto New York State Thruway
227 mi · 04h 23m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Rain Showers then Partly Sunny leaving Cairo and Slight Chance Rain Showers then Mostly Sunny near Buffalo.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Cairo to Buffalo?
The road trip is about 296 miles (476.3 km) and usually takes 05h 01m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Mattydale is a useful midpoint, sitting about 146.8 miles from Cairo and 149.1 miles from Buffalo.
How much longer is the road route than the straight-line distance?
The direct path is about 251.5 miles (404.7 km), while the road route adds roughly 44.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM EDT. If you want a more comfortable same-day return, try to leave by 6:56 AM EDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $41.85 one way or $83.71 round trip. Estimated CO2 is about 92.8 kg one way.
What should you check before leaving?
Before you leave, expect Chance Rain Showers then Partly Sunny around Cairo and Slight Chance Rain Showers then Mostly Sunny near Buffalo.
Stop Ideas Near Mattydale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
City Hall Cafe
Syracuse City Hall
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Mattydale.
William F. Walsh Regional Transportation Center
Empire Expo Center
Rome station
Union Station
Flight Path Map
This map shows the direct air route between Cairo and Buffalo. Straight-line distance: 251.48 mi (404.71 km).
#1 Cairo
Town in Greene County, New York, United States
| Population | 6,420 |
| Coordinates | 42.2989700, -73.9984700 |
| Altitude | 114 |
| Country | United States |
#2 Buffalo
The second most populous city in New York.
| Population | 254,479 |
| Coordinates | 42.8864500, -78.8783700 |
| Altitude | 183 |
| Country | United States |
End: Niagara Square (-78.878786, 42.886515)
Estimated Travel Time
Distance: 476 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 09h 51m |
| 40 mph (64.37 km/h) | 07h 23m |
| 50 mph (80.47 km/h) | 05h 55m |
| 60 mph (96.56 km/h) | 04h 55m |
| 70 mph (112.65 km/h) | 04h 13m |
| 80 mph (129 km/h) | 03h 41m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $4.01 | $41.85 | $83.71 |
| Mid-grade | $4.48 | $46.78 | $93.56 |
| Premium | $4.86 | $50.75 | $101.50 |
| Diesel | $4.69 | $49.01 | $98.01 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in New York · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.