How far is Appleton City, MO from St. Louis, MO?
The driving distance from Appleton City, MO to St. Louis, MO is about 261.1 miles (420.2 km), with a travel time of about 04h 18m by car.
- The straight-line flight distance is about 209.6 miles (337.3 km).
- For a round trip, plan for roughly 08h 37m of driving time before adding stops, traffic, or weather delays.
- A comfortable departure window is usually 6:00 AM to 8:00 AM CDT.
Reverse, save, or send this route
This drive is better planned with a longer stop or an overnight stay. Copy the route link, send it to another device, or print a clean version before you head out.
This drive is better planned with a longer stop or an overnight stay.
Flight Distance
Driving Distance
Gas Cost Calculator
Leave and Arrive Planner
Pick a departure time to see your estimated arrival and same-day return window.
Drive time stays fixed at 04h 18m.
An early departure helps you fit a real stop into the day without turning the return into a late-night drive.
This departure sits inside the recommended comfort window for the route.
Halfway Point
A useful midpoint for breaks, coffee, or meeting in the middle.
Human settlement in Missouri, United States of America
Route Weather Snapshot
Check the forecast at both ends before you head out.
Chance Showers And Thunderstorms
Mostly Sunny
Driving Route Map
The map below follows the saved road route between Appleton City and St. Louis.
Turn-by-Turn Driving Directions
Step-by-step road directions between Appleton City and St. Louis.
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1
Start on North Walnut Street
4 m · 6 sec · North Walnut Street
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2
Turn left onto West 4th Street
3.8 mi · 7 min · West 4th Street
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3
Keep slight left
3 mi · 5 min
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4
Keep slight right
12.1 mi · 21 min
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5
Take the ramp left toward MO 13 North, MO 52 East: Clinton
9.2 mi · 12 min
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6
Take the exit slight right toward MO 52 West: Calhoun, Windsor
1827 ft · 52 sec
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7
At the end of the road, turn right
30.2 mi · 45 min
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8
Turn left
30.3 mi · 38 min
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9
Take the exit slight right toward I 70 East: Saint Louis
1866 ft · 40 sec
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10
Merge slight left onto U.S. Submarine Veterans' Memorial Highway
22.9 mi · 25 min · U.S. Submarine Veterans' Memorial Highway
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11
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22.4 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
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12
Continue on Dwight D. Eisenhower Highway
1.8 mi · 2 min · Dwight D. Eisenhower Highway
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13
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi · 2 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
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14
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
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15
Continue on Dwight D. Eisenhower Highway
81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
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16
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
1567 ft · 33 sec
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17
Merge slight left onto Avenue of the Saints
27.7 mi · 34 min · Avenue of the Saints
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18
Continue on Daniel Boone Expressway
5.7 mi · 7 min · Daniel Boone Expressway
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19
Continue on Jack Buck Memorial Highway
5.8 mi · 7 min · Jack Buck Memorial Highway
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20
Take the exit slight right toward 14th Street
1115 ft · 34 sec
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21
Turn left onto South 14th Street
1715 ft · 42 sec · South 14th Street
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22
Turn right onto Market Street
956 ft · 25 sec · Market Street
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23
Arrive at your destination
0 m · 1 sec · Market Street
Car Route Details
A richer read on the saved driving route between Appleton City and St. Louis.
Highway-focused drive
Most of the mileage stays on named highways, so the important moments are ramps, exits, merges, and the final local approach.
Dwight D. Eisenhower Highway
Continue on Dwight D. Eisenhower Highway
81 mi · 01h 35m
Route Summary
A quick read on whether this route feels easy, ambitious, or worth planning around.
A longer out-and-back drive
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
Chance Showers And Thunderstorms leaving Appleton City and Mostly Sunny near St. Louis.
Trip Questions
Direct answers travelers usually want before committing to the drive.
How long does it take to drive from Appleton City to St. Louis?
The road trip is about 261.1 miles (420.2 km) and usually takes 04h 18m in normal driving conditions.
Is this a same-day trip or an overnight route?
This is still possible in one day, but it becomes a long driving day. Leaving early and planning your stop window matters more here.
What is the halfway point on this route?
Huntsdale is a useful midpoint, sitting about 130.4 miles from Appleton City and 130.7 miles from St. Louis.
How much longer is the road route than the straight-line distance?
The direct path is about 209.6 miles (337.3 km), while the road route adds roughly 51.5 extra miles because roads do not follow the straight air line.
When is the best time to leave for this route?
A good departure window is usually 6:00 AM to 8:00 AM CDT. If you want a more comfortable same-day return, try to leave by 8:22 AM CDT.
How much will gas cost for this route?
Using about 28.3 MPG, regular gas is estimated at $34.73 one way or $69.46 round trip. Estimated CO2 is about 81.8 kg one way.
What should you check before leaving?
Before you leave, expect Chance Showers And Thunderstorms around Appleton City and Mostly Sunny near St. Louis.
Stop Ideas Near Huntsdale
Useful break, food, and waypoint ideas within about 15 miles of the route midpoint.
Transit and Meeting Points
Useful pickup, handoff, or rendezvous points close to Huntsdale.
Jefferson City
Sedalia
Hermann
Warrensburg
Flight Path Map
This map shows the direct air route between Appleton City and St. Louis. Straight-line distance: 209.61 mi (337.33 km).
#1 Appleton City
City in St.
| Population | 1,080 |
| Coordinates | 38.1905800, -94.0293900 |
| Altitude | 267 |
| Country | United States |
#2 St. Louis
The second most populous city in Missouri and the center of the St.
| Population | 315,685 |
| Coordinates | 38.6272700, -90.1978900 |
| Altitude | 142 |
| Country | United States |
End: Market Street (-90.197859, 38.627348)
Estimated Travel Time
Distance: 420 km by road
| Speed | Time |
|---|---|
| 30 mph (48.3 km/h) | 08h 42m |
| 40 mph (64.37 km/h) | 06h 31m |
| 50 mph (80.47 km/h) | 05h 13m |
| 60 mph (96.56 km/h) | 04h 21m |
| 70 mph (112.65 km/h) | 03h 43m |
| 80 mph (129 km/h) | 03h 15m |
Fuel, Round Trip and CO2
Estimated fuel cost and emissions for this route.
| Fuel | $/gal | One way | Round trip |
|---|---|---|---|
| Regular gas | $3.77 | $34.73 | $69.46 |
| Mid-grade | $4.25 | $39.17 | $78.34 |
| Premium | $4.65 | $42.86 | $85.73 |
| Diesel | $5.30 | $48.85 | $97.70 |
Assumes 8.3 L/100 km (about 28.3 MPG). CO2 is an estimate and varies by vehicle, fuel blend, traffic, and terrain.
Prices in Missouri · Apr 23, 2026
Distance to Other Cities
Planning a road trip? See the full trip guide on Trip.ovh — stops, fuel costs, weather, and departure timing.